Is 2-Methyl-3-Buten-2-Ol safe in cosmetics?
2-Methyl-3-Buten-2-Ol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
2-Methyl-3-Buten-2-Ol
Also known as: 4-01-00-02132, BRN 1698263, 1,1-Dimethylallyl alchol, alpha,alpha-Dimethylallyl alcohol, 1,1-Dimethyl-2-propanol (+4 more)
2-Methyl-3-Buten-2-Ol (CAS 115-18-4) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 115-18-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Methyl-3-Buten-2-Ol is classified GHS Danger (H225, H302, H319, H336, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Flavouring and nutrient; Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-methylbut-3-en-2-ol
InChIKey
HNVRRHSXBLFLIG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; RIFM-assessed for fragrance safety
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Methyl-3-Buten-2-Ol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2-Methyl-3-Buten-2-Ol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarn
Hazard Statements
Highly flammable liquid and vapour Harmful if swallowed Causes eye irritation
Short-term Exposure Effects
The substance is irritating to the eyes.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Methyl-3-Buten-2-Ol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1719
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-Methyl-3-Buten-2-Ol.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Methyl-3-Buten-2-Ol by CAS number or substance name.
Studies
1
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
4-01-00-02132
BRN 1698263
1,1-Dimethylallyl alchol
alpha,alpha-Dimethylallyl alcohol
1,1-Dimethyl-2-propanol
1,1-Dimethyl-2-propenol
EINECS 204-068-4
3-Methyl-buten-(1)-ol-(3)
UNII-SH64HE46L9
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
active_ingredient; Europe; Pesticides
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4245903
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-METHYL-3-BUTEN-2-OL
Food Category
flavoring
Frequently Asked Questions
Is 2-Methyl-3-Buten-2-Ol allowed in the EU?
2-Methyl-3-Buten-2-Ol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Methyl-3-Buten-2-Ol do in cosmetics?
2-Methyl-3-Buten-2-Ol functions as: Flavouring and nutrient; Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 115-18-4.
What is the NOAEL for 2-Methyl-3-Buten-2-Ol?
The NOAEL (No Observed Adverse Effect Level) for 2-Methyl-3-Buten-2-Ol is =150 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 2-Methyl-3-Buten-2-Ol classified as hazardous under GHS?
2-Methyl-3-Buten-2-Ol carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is 2-Methyl-3-Buten-2-Ol used outside cosmetics?
2-Methyl-3-Buten-2-Ol also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Methyl-3-Buten-2-Ol have different safety status in cosmetics vs industrial chemicals?
2-Methyl-3-Buten-2-Ol is classified GHS Danger (H225, H302, H319, H336, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-Methyl-3-Buten-2-Ol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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