What is the NOAEL for 1,3-Propanediol, 2-amino-2-methyl-?
1,3-Propanediol, 2-amino-2-methyl- has 7 NOAEL studies in the database. The lowest reported value is 5.17 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Propanediol, 2-amino-2-methyl-
Also known as: 4-04-00-01881, 2-Amino-2-methylpropanediol, BRN 0635708, EINECS 204-100-7, UNII-CZ7BU4QZJZ (+4 more)
CAS 115-69-5
1,3-Propanediol, 2-amino-2-methyl- (CAS 115-69-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
1,3-Propanediol, 2-amino-2-methyl- is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is restricted in EU cosmetics at max Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
1,3-Propanediol, 2-amino-2-methyl-
CAS Number
115-69-5
DTXSID
DTXSID7059430
Molecular Formula
C4H11NO2
InChI Key
UXFQFBNBSPQBJW-UHFFFAOYSA-N
Monoisotopic Mass
105.078979
Synonyms
4-04-00-018812-Amino-2-methylpropanediolBRN 0635708EINECS 204-100-7UNII-CZ7BU4QZJZAMPDAminomethyl propanediolisobutandiol-2-aminepentaerythritol dichlorohydrin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
pH regulating agentFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5.17 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| CZ7BU4QZJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CZ7BU4QZJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CZ7BU4QZJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CZ7BU4QZJZ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =17000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =100 | mg/m3 | NOAEC | inhalation | Hamster | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-amino-2-methylpropane-1,3-diol | 204-100-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg
Category
Other
Frequently Asked Questions
What regulatory lists include 1,3-Propanediol, 2-amino-2-methyl-?
1,3-Propanediol, 2-amino-2-methyl- appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.
Is 1,3-Propanediol, 2-amino-2-methyl- used in cosmetics?
Yes, 1,3-Propanediol, 2-amino-2-methyl- is also indexed as a cosmetic ingredient under the name Aminomethyl Propanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Propanediol, 2-amino-2-methyl- come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,3-Propanediol, 2-amino-2-methyl- have different safety status in cosmetics vs industrial chemicals?
1,3-Propanediol, 2-amino-2-methyl- is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is restricted in EU cosmetics at max Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg.
Is 1,3-Propanediol, 2-amino-2-methyl- used outside industrial chemicals?
1,3-Propanediol, 2-amino-2-methyl- also appears in cosmetics databases.