Is Aminomethyl Propanediol safe in cosmetics?
Aminomethyl Propanediol has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Aminomethyl Propanediol
Also known as: 4-04-00-01881, 2-Amino-2-methylpropanediol, BRN 0635708, EINECS 204-100-7, UNII-CZ7BU4QZJZ (+3 more)
INCI: AMINOMETHYL PROPANEDIOL
Aminomethyl Propanediol (CAS 115-69-5) is a cosmetic cosmetic ingredient functioning as pH adjuster (buffering agent), Fragrance ingredient. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 115-69-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Aminomethyl Propanediol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is restricted in EU cosmetics at max Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
pH adjuster (buffering agent), Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-amino-2-methylpropane-1,3-diol
InChIKey
UXFQFBNBSPQBJW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg
US US Status
permitted
US Notes
No specific FDA restrictions; reported in 133 VCRP formulations predominantly eye area (121 products)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminomethyl Propanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Aminomethyl Propanediol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
pH regulating agent
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Aminomethyl Propanediol.
Regulatory Flags
Restricted
ifra_fragrance
Known Synonyms
4-04-00-01881
2-Amino-2-methylpropanediol
BRN 0635708
EINECS 204-100-7
UNII-CZ7BU4QZJZ
AMPD
isobutandiol-2-amine
pentaerythritol dichlorohydrin
Chemical Function
pH regulating agent
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Aminomethyl Propanediol allowed in the EU?
Aminomethyl Propanediol EU regulatory status: restricted. Maximum allowed concentration: Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminomethyl Propanediol do in cosmetics?
Aminomethyl Propanediol functions as: pH adjuster (buffering agent), Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 115-69-5.
Is Aminomethyl Propanediol used outside cosmetics?
Aminomethyl Propanediol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aminomethyl Propanediol have different safety status in cosmetics vs industrial chemicals?
Aminomethyl Propanediol is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is restricted in EU cosmetics at max Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg.
Compliance Tools
Check Aminomethyl Propanediol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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