Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Aminomethyl Propanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Permitted in EU with alkanolamine restrictions (Annex III Entry 61: secondary amine ≤0.5%, nitrosamine ≤50 ug/kg). CIR concluded safe as used at up to 2% in leave-on products.
Regulatory Flags
Frequently Asked Questions
Is Aminomethyl Propanediol safe in cosmetics?
Permitted in EU with alkanolamine restrictions (Annex III Entry 61: secondary amine ≤0.5%, nitrosamine ≤50 ug/kg). CIR concluded safe as used at up to 2% in leave-on products. The EU classifies Aminomethyl Propanediol as "restricted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Aminomethyl Propanediol allowed in the EU?
Aminomethyl Propanediol EU regulatory status: restricted. Maximum allowed concentration: Secondary amine content max 0.5%; nitrosamine content max 50 ug/kg. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminomethyl Propanediol do in cosmetics?
Aminomethyl Propanediol functions as: pH adjuster (buffering agent), Fragrance ingredient. It is classified as a Cosmetic Ingredient in our database. CAS number: 115-69-5.
What is the Margin of Safety for Aminomethyl Propanediol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Aminomethyl Propanediol?
The NOAEL (No Observed Adverse Effect Level) for Aminomethyl Propanediol is 500 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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