What is the NOAEL for 2-Amino-2-ethyl-1,3-propanediol?
2-Amino-2-ethyl-1,3-propanediol has 6 NOAEL studies in the database. The lowest reported value is 58.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Amino-2-ethyl-1,3-propanediol
Also known as: 1,3-Propanediol, 2-amino-2-ethyl-, (1,1-Bis(hydroxymethyl)propyl)amine, 2-Amino-2-ethylpropan-1,3-diol, 2-Amino-2-ethylpropanediol, 2-Ethyl-2-amino-1,3-propanediol (+8 more)
CAS 115-70-8
2-Amino-2-ethyl-1,3-propanediol (CAS 115-70-8) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Aminoethyl Propanediol (AEPD) →
Cross-Vertical Regulatory Divergence
2-Amino-2-ethyl-1,3-propanediol is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
2-Amino-2-ethyl-1,3-propanediol
CAS Number
115-70-8
DTXSID
DTXSID3029150
Molecular Formula
C5H13NO2
InChI Key
IOAOAKDONABGPZ-UHFFFAOYSA-N
Monoisotopic Mass
119.094629
Synonyms
1,3-Propanediol, 2-amino-2-ethyl-(1,1-Bis(hydroxymethyl)propyl)amine2-Amino-2-ethylpropan-1,3-diol2-Amino-2-ethylpropanediol2-Ethyl-2-amino-1,3-propanediolAEPDAEPD-VOX 1000VOX 1000EINECS 204-101-22-Ethyl-2-aminopropanediolNSC 8803UNII-0ADF1987D4
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
pH regulating agent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =58.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0ADF1987D4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ADF1987D4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ADF1987D4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0ADF1987D4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-amino-2-ethylpropanediol | 204-101-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL119482
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
Is 2-Amino-2-ethyl-1,3-propanediol used in cosmetics?
Yes, 2-Amino-2-ethyl-1,3-propanediol is also indexed as a cosmetic ingredient under the name Aminoethyl Propanediol (AEPD). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Amino-2-ethyl-1,3-propanediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Amino-2-ethyl-1,3-propanediol have different safety status in cosmetics vs industrial chemicals?
2-Amino-2-ethyl-1,3-propanediol is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics.
Is 2-Amino-2-ethyl-1,3-propanediol used outside industrial chemicals?
2-Amino-2-ethyl-1,3-propanediol also appears in cosmetics, pharmaceutical databases.