What is the NOAEL for Safranal?
Safranal has 22 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Safranal
Also known as: Dehydro-beta-cyclocitral, EINECS 204-133-7, FEMA No. 3389, 2,6,6-Trimethyl-1,3-cyclohexadienal, (2,6,6-Trimethylcyclohexa-1,3-dienyl)methanal (+4 more)
CAS 116-26-7
Safranal (CAS 116-26-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for 2,3-Dihydro-2,2,6-trimethylbenzaldehyde (Safranal) →
SOURCE
NOAEL studies
NOAEL studies
22
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Safranal
CAS Number
116-26-7
Molecular Formula
C10H14O
InChI Key
SGAWOGXMMPSZPB-UHFFFAOYSA-N
Monoisotopic Mass
150.104465
Synonyms
Dehydro-beta-cyclocitralEINECS 204-133-7FEMA No. 33892,6,6-Trimethyl-1,3-cyclohexadienal(2,6,6-Trimethylcyclohexa-1,3-dienyl)methanalUNII-4393FR07EA1,1,3-Trimethyl-2-formylcyclohexa-2,4-diene2,6,6-Trimethylcyclohexa-1,3-dienyl methanal2,6,6-trimethyl-1,3-cyclohexadiene-1-carboxaldehyde
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 12.4 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 0.27 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.1 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =3.08 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 91.8 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 5.39 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 7.5 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 4393FR07EA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 337.3 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 339.1 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 9.434 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 300 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 160 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 60 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =120 | mg/kg bw/day | LEL | oral | Rat | EFSA |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =10 | mg/kg bw/day | NOEL | oral | Rat | EFSA |
| =10 | mg/kg bw/day | NOEL | - | Rat | EFSA |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,3-dihydro-2,2,6-trimethylbenzaldehyde | 204-133-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3183495
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Safranal?
Safranal appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Safranal used in cosmetics?
Yes, Safranal is also indexed as a cosmetic ingredient under the name 2,3-Dihydro-2,2,6-trimethylbenzaldehyde (Safranal). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Safranal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Safranal used outside industrial chemicals?
Safranal also appears in cosmetics, pharmaceutical, cannabis databases.