Warning GHS07 NOAEL Data Cosmetic Ingredient

Lauryl gallate

Also known as: Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester, 4-10-00-02006, BRN 2701981, EINECS 214-620-6, Gallic acid, dodecyl ester (+7 more)

CAS 1166-52-5

Lauryl gallate (CAS 1166-52-5) is a chemical substance with GHS signal word Warning; key hazard signal: H317. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Dodecyl Gallate →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Lauryl gallate

CAS Number

1166-52-5

DTXSID

DTXSID0048189

Molecular Formula

C19H30O5

InChI Key

RPWFJAMTCNSJKK-UHFFFAOYSA-N

Monoisotopic Mass

338.209324

Synonyms

Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester4-10-00-02006BRN 2701981EINECS 214-620-6Gallic acid, dodecyl esterGallic acid, lauryl esterLauryl 3,4,5-trihydroxybenzoateNipagallin LANSC 133463Progallin LADodecylester kyseliny galloveUNII-45612DY463

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Skin Sens. 1	H317	GHS07	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Antioxidant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
animal_products	USDA	United States Department of Agriculture (USDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 29 of 29 studies

Value	Unit	Endpoint	Route	Species	Source
15.4568866128783	uM	AC50	-	-	NTP_ICE_endocrine
30.8447321448957	uM	AC50	-	-	NTP_ICE_endocrine
10.1116775674295	uM	ACC	-	-	NTP_ICE_endocrine
23.5273699154343	uM	ACC	-	-	NTP_ICE_endocrine
2.91	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
0.7	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
2.02	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
>2369.108	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
8.2	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
-	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
90.9	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
8.7	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
49.8	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
1.107	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
0.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
0.3	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
>2000	uM	EC3	Dermal	-	NTP_ICE_skin_sensitization
45612DY463	UNII	FDA UNII substance identifier	-	-	openFDA substances
45612DY463	UNII	FDA UNII substance identifier	-	-	openFDA substances
45612DY463	UNII	FDA UNII substance identifier	-	-	openFDA substances
45612DY463	UNII	FDA UNII substance identifier	-	-	openFDA substances
2.2e-8	fraction	Fu	-	Human	NTP_ICE_adme_parameters
8.76	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
2.52	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0773	unitless	Model Score	-	-	NTP_ICE_endocrine
0.177	unitless	Model Score	-	-	NTP_ICE_endocrine

Showing 29 of 29 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DODECYL GALLATE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E312 — ADI: 1.4 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Lauryl gallate?

Lauryl gallate (CAS 1166-52-5) is classified under EU CLP Annex VI as Skin Sens. 1 with signal word Warning. Hazard statements: H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Lauryl gallate?

Lauryl gallate has 29 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Lauryl gallate?

Lauryl gallate appears on 2 regulatory/inventory lists including animal_products, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.

Is Lauryl gallate used in cosmetics?

Yes, Lauryl gallate is also indexed as a cosmetic ingredient under the name Dodecyl Gallate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Lauryl gallate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Lauryl gallate used outside industrial chemicals?

Lauryl gallate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.