Is Dodecyl Gallate safe in cosmetics?
Dodecyl Gallate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dodecyl Gallate
Also known as: Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester, 4-10-00-02006, BRN 2701981, EINECS 214-620-6, Gallic acid, dodecyl ester (+7 more)
INCI: DODECYL GALLATE
Dodecyl Gallate (CAS 1166-52-5) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1166-52-5 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dodecyl 3,4,5-trihydroxybenzoate
InChIKey
RPWFJAMTCNSJKK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted as GRAS food-grade antioxidant; no 21 CFR cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dodecyl Gallate.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1
Hazard Statements
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
90.9%
DPRA Lys %
8.7%
KeratinoSens IC50
8.76 µM
hCLAT CV75
8.2 µg/mL
LLNA EC3
0.3%
NESIL
75 µg/cm²
LLNA: Strong (1A)
GHS: 1A
Source: LLNA: Gerberick et al. (2005); DPRA: Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868]; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ
LOEC: 10 µM
EU status: allowed
agonist (weak)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Evaluation
DODECYL GALLATE | 1996 | NO ADI ALLOCATED | The temporary ADI allocated at the forty-first meeting (1993) was not extended | TRS 868-JECFA 46/15
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dodecyl Gallate.
Regulatory Flags
fda_food_additive
jecfa_concern
Known Synonyms
Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester
4-10-00-02006
BRN 2701981
EINECS 214-620-6
Gallic acid, dodecyl ester
Gallic acid, lauryl ester
Lauryl 3,4,5-trihydroxybenzoate
Nipagallin LA
NSC 133463
Progallin LA
Dodecylester kyseliny gallove
UNII-45612DY463
Chemical Function
Antioxidant
Regulatory Lists
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DODECYL GALLATE
ChEMBL ID
CHEMBL16121
Frequently Asked Questions
Is Dodecyl Gallate allowed in the EU?
Dodecyl Gallate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dodecyl Gallate do in cosmetics?
Dodecyl Gallate functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 1166-52-5.
Is Dodecyl Gallate used outside cosmetics?
Dodecyl Gallate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dodecyl Gallate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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