What is the NOAEL for 3,3,5-Trimethylcyclohexyl salicylate?
3,3,5-Trimethylcyclohexyl salicylate has 37 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,3,5-Trimethylcyclohexyl salicylate
Also known as: 3,3,5-Trimethylcyclohexylsalicylate (Homosalate), Homosalate, Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester, Caswell No. 482B, Coppertone (+10 more)
CAS 118-56-9
3,3,5-Trimethylcyclohexyl salicylate (CAS 118-56-9) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
Cross-Vertical Regulatory Divergence
3,3,5-Trimethylcyclohexyl salicylate is classified GHS CMR hazard (H315, H319, H335, H361d, H410) in the chemicals database but is restricted in EU cosmetics at max 7.34%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
37
SOURCE
Chemical inventory jurisdictions
Regulatory lists
7
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
3,3,5-Trimethylcyclohexyl salicylate
CAS Number
118-56-9
Molecular Formula
C16H22O3
InChI Key
WSSJONWNBBTCMG-UHFFFAOYSA-N
Monoisotopic Mass
262.156895
Synonyms
3,3,5-Trimethylcyclohexylsalicylate (Homosalate)HomosalateBenzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl esterCaswell No. 482BCoppertoneEINECS 204-260-8EPA Pesticide Chemical Code 076603Filtersol ''A''Heliopanm-Homomenthyl salicylateNSC 164918Salicylic acid, m-homomenthyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
UV stabilizerSoftener and conditionerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 37 of 37 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.5 | % | - | oral | - | Regulatory source |
| 9 | - | - | - | - | Regulatory source |
| 10 | mg/kg bw/day | - | oral | - | Regulatory source |
| 43 | mg/kg/day | - | oral | rat | Regulatory source |
| 75 | mg/kg | - | oral | rat | Regulatory source |
| 75 | mg/kg bw/d | - | - | human | Regulatory source |
| 100 | mg/kg bw | - | - | rat | Regulatory source |
| 120 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 300 | mg/kg bw/day | - | - | - | Regulatory source |
| 31.3 | uM | AC50 | - | - | NTP ICE endocrine |
| 15.34 | uM | ACC | - | - | NTP ICE endocrine |
| =16.09 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| V06SV4M95S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =750 | mg/kg bw/day | LEL | oral | Rat | ToxValDB EPA TSCA 8e |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB EPA TSCA 8e |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0217 | unitless | Model Score | - | - | NTP ICE endocrine |
| =0.5 | % | NOAEL | oral | - | SCCS Opinion |
| =2 | % | NOAEL | oral | human | SCCS Opinion |
| =9 | - | NOAEL | - | - | SCCS Opinion |
| =10 | mg/kg bw/day | NOAEL | oral | - | SCCS Opinion |
| =10 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =20 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =43 | mg/kg/day | NOAEL | oral | rat | SCCS Opinion |
| =50 | % | NOAEL | oral | - | SCCS Opinion |
| =50 | % | NOAEL | oral | human | SCCS Opinion |
| =75 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =75 | mg/kg bw/d | NOAEL | - | human | SCCS Opinion |
| =100 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =100 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =120 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB EPA TSCA 8e |
| =120 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =300 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =300 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| =300 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
Showing 37 of 37 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Homosalate | 204-260-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1638/21 | 2 December 2021 | safe with restrictions | up to 7.34% | Potential endocrine disrupting properties; reproductive toxicity concerns from OECD 422 study; assessment covers dermal application only |
| SCCS/1622/20 | 24-25 June 2021 | safe with restrictions | up to 0.5% (full body products); 7.34% established in subsequent SCCS/1638/21 | Potential endocrine disrupting properties (equivocal evidence); reproductive/developmental toxicity based on LOAEL 60 mg/kg bw/d; MoS insufficient at 10% |
| SCCP/1039/06 | 21 March 2007 | safe | up to 10% | No significant endocrine disrupting properties identified at time of opinion (2007); MoS >100 based on NOAEL of 100 mg/kg bw/d from 14-day study; subsequently found insufficient by SCCS/1622/20 |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
7.34%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
HOMOSALATE
ChEMBL Phase
2
Adverse Events
95
Bioactivity
3
Frequently Asked Questions
What regulatory lists include 3,3,5-Trimethylcyclohexyl salicylate?
3,3,5-Trimethylcyclohexyl salicylate appears on 6 regulatory/inventory lists including Europe; Personal care, Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, and 3 more. Source: EPA CPDat.
Is 3,3,5-Trimethylcyclohexyl salicylate used in cosmetics?
Yes, 3,3,5-Trimethylcyclohexyl salicylate is also indexed as a cosmetic ingredient under the name Homosalate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,3,5-Trimethylcyclohexyl salicylate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 3,3,5-Trimethylcyclohexyl salicylate have different safety status in cosmetics vs industrial chemicals?
3,3,5-Trimethylcyclohexyl salicylate is classified GHS CMR hazard (H315, H319, H335, H361d, H410) in the chemicals database but is restricted in EU cosmetics at max 7.34%.
Is 3,3,5-Trimethylcyclohexyl salicylate used outside industrial chemicals?
3,3,5-Trimethylcyclohexyl salicylate also appears in cosmetics, pharmaceutical databases.