What is the GHS hazard classification for Benzyl salicylate?
Benzyl salicylate (CAS 118-58-1) is classified under EU CLP Annex VI as Skin Sens. 1B with signal word Warning. Hazard statements: H317. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzyl salicylate
Also known as: Benzoic acid, 2-hydroxy-, phenylmethyl ester, 4-10-00-00157, Benzyl o-hydroxybenzoate, BRN 2115365, EINECS 204-262-9 (+5 more)
CAS 118-58-1
Benzyl salicylate (CAS 118-58-1) is a chemical substance with GHS signal word Warning; key hazard signal: H317. Key regulatory status: REACH registered, 30 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
60
SOURCE
Chemical inventory jurisdictions
Regulatory lists
30
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Benzyl salicylate
CAS Number
118-58-1
Molecular Formula
C14H12O3
InChI Key
ZCTQGTTXIYCGGC-UHFFFAOYSA-N
Monoisotopic Mass
228.078644
Synonyms
Benzoic acid, 2-hydroxy-, phenylmethyl ester4-10-00-00157Benzyl o-hydroxybenzoateBRN 2115365EINECS 204-262-9FEMA No. 2151NSC 6647Salicyclic acid, benzyl esterSalicylsaeurebenzylesterUNII-WAO5MNK9TU
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Sens. 1B | H317 | GHS07 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceUV stabilizerBiocideDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
30 records
| List | Keyword | Source |
|---|---|---|
| Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash; Personal care - fragrance; Personal care - general moisturizing - hand/body lotion; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - general household cleaning; Cleaning products and household care - laundry and fabric treatment; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 60 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0 | - | - | oral | rat | Regulatory source |
| 3.4 | - | - | oral | - | Regulatory source |
| 4 | mg/kg/day | - | oral | - | Regulatory source |
| 14 | - | - | oral | - | Regulatory source |
| 21 | - | - | oral | - | Regulatory source |
| 24 | - | - | dermal | - | Regulatory source |
| 26 | - | - | oral | rat | Regulatory source |
| 75 | mg/kg/day | - | - | - | Regulatory source |
| 123 | - | - | - | - | Regulatory source |
| 123 | - | - | oral | - | Regulatory source |
| 400 | mg/kg/d | - | oral | - | Regulatory source |
| 451 | - | - | oral | - | Regulatory source |
| 3000 | ppm | - | oral | rat | Regulatory source |
| 6000 | ppm | - | oral | - | Regulatory source |
| 53.92 | uM | AC50 | - | - | NTP ICE endocrine |
| 42.93 | uM | ACC | - | - | NTP ICE endocrine |
| 66.17 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 38 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 841 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 12.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 25 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 10 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 20 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =7.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 3.8 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 1.5 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 8.422 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 2.8 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 2.9 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 40.88 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| WAO5MNK9TU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3.350e-8 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 111 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 5.51 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 8 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6200 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 1.350e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 1.772e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 1.944e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 2.025e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 8438 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.688e+4 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6750 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =2227 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =3.7 | mg/kg bw/day | LEL | oral | Rat | ToxValDB Uterotrophic Hershberger DB |
| =11.1 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB Uterotrophic Hershberger DB |
| 3.7 | mg/kg bw/day | LOEL | Oral | Rat | NTP ICE endocrine |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 50 of 60 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzyl salicylate | 204-262-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1656/23 | 26 October 2023 | Safe with restrictions per Table 1 concentration limits | Up to 0.91% depending on product type per Table 1; e.g. 0.29% leave-on face products | Established contact allergen; potential endocrine mode of action (no conclusive adverse effects); hydrolyses to salicylic acid and benzyl alcohol |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
BENZYL SALICYLATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Benzyl salicylate?
Benzyl salicylate has 60 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in rat. Source: Regulatory source.
What regulatory lists include Benzyl salicylate?
Benzyl salicylate appears on 21 regulatory/inventory lists including Europe, inert_ingredient; non_food_use; Pesticides, Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; detected; Europe; Vehicle - car interior - auto air freshener, and 18 more. Source: EPA CPDat.
Is Benzyl salicylate used in cosmetics?
Yes, Benzyl salicylate is also indexed as a cosmetic ingredient under the name Benzyl Salicylate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzyl salicylate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzyl salicylate used outside industrial chemicals?
Benzyl salicylate also appears in cosmetics, pharmaceutical, cannabis databases.