Benzyl Salicylate
INCI: BENZYL SALICYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Benzyl Salicylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =166 mg/kg/day | oral | rat (male) | subchronic | SCCS |
| NOAEL | 166 mg/kg bw/day | oral | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 214 mg/kg bw/day | oral | rat | reproductive | SCCS_PDF_extraction |
| NOAEL | 214 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 214 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
| NOAEL | 400 mg/kg bw/day | oral | - | chronic | SCCS_PDF_extraction |
| NOAEL | 166 mg/kg bw/day | - | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 75 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
| NOAEL | 204 mg/kg bw/day | oral | - | subchronic | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
meeting, issued a Final Amended Report with the conclusion that salicylic acid and salicylate ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating and non- sensitizing, which may be based on a quantitative risk
meeting, issued a Final Amended Report with the conclusion that salicylic acid and salicylate ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating and non- sensitizing, which may be based on a quantitative risk
SCCS NOAEL Values
NOAEL/LOAEL values cited in official SCCS opinions for Benzyl Salicylate.
| NOAEL | LOAEL | Route | Species | Study | DA% (SCCS) | Opinion |
|---|---|---|---|---|---|---|
| 75 mg/kg/day | - | Oral | Rat (Wistar) | Developmental toxicity (read-across from salicylic acid) (GD 8-14) | 100 | SCCS/1656/23 (2023) |
Sensitization Profile
Contact sensitization data for Benzyl Salicylate based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Benzyl Salicylate, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
EU declarable fragrance allergen with mandatory labelling above threshold limits; restricted as a key IFRA component in ylang ylang and other floral fragrances with moderate to high sensitization risk.
Regulatory Flags
Frequently Asked Questions
Is Benzyl Salicylate safe in cosmetics?
EU declarable fragrance allergen with mandatory labelling above threshold limits; restricted as a key IFRA component in ylang ylang and other floral fragrances with moderate to high sensitization risk. The EU classifies Benzyl Salicylate as "restricted". Safety rating: MODERATE. 9 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir and sccs.
Is Benzyl Salicylate allowed in the EU?
Benzyl Salicylate EU regulatory status: restricted. Maximum allowed concentration: Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzyl Salicylate do in cosmetics?
Benzyl Salicylate functions as: fragrance; UV-absorber. It is classified as a Fragrance in our database. CAS number: 118-58-1.
What is the Margin of Safety for Benzyl Salicylate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Benzyl Salicylate?
The NOAEL (No Observed Adverse Effect Level) for Benzyl Salicylate is =166 mg/kg/day based on a subchronic study via oral route in rat (male). A total of 9 study endpoints are available. Source: SCCS.
Compliance Tools
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