NOAEL Data REACH Registered Cosmetic Ingredient

Maltol

Also known as: 5-18-01-00114, BRN 0112169, Corps praline, EINECS 204-271-8, FEMA No. 2656 (+8 more)

CAS 118-71-8

Maltol (CAS 118-71-8) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Maltol →

Cross-Vertical Regulatory Divergence

Maltol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H341, H315, H319, H335).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields

Name

Maltol

CAS Number

118-71-8

DTXSID

DTXSID0025523

Molecular Formula

C6H6O3

InChI Key

XPCTZQVDEJYUGT-UHFFFAOYSA-N

Monoisotopic Mass

126.031694

Synonyms

5-18-01-00114BRN 0112169Corps pralineEINECS 204-271-8FEMA No. 26563-Hydroxy-2-methyl-gamma-pyrone2-Methyl pyromeconic acid2-Methyl-3-oxy-gamma-pyrone2-Methylpyromeconic acidUNII-3A9RD92BS43-hydroxy-2-methyl-pyran-4-one3-hydroxy-2-methylpyran-4-one

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 50 records

DeodorizerHumectantFlavouring and nutrientFragranceProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies

Value	Unit	Endpoint	Route	Species	Source
<=1	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
=1	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=1	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=6.58	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
3A9RD92BS4	UNII	FDA UNII substance identifier	-	-	openFDA substances
3A9RD92BS4	UNII	FDA UNII substance identifier	-	-	openFDA substances
3A9RD92BS4	UNII	FDA UNII substance identifier	-	-	openFDA substances
3A9RD92BS4	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
6480	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=1410	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
-	unitless	Model Score	-	-	NTP_ICE_endocrine
200	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
300	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
400	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
500	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=100	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_EFSA
=100	mg/kg bw/day	NOEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=100	mg/kg bw/day	NOEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 21 of 21 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	3-hydroxy-2-methyl-4-pyrone	204-271-8	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL MALTOL

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E636 — ADI: 1 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Maltol?

Maltol has 21 NOAEL studies in the database. The lowest reported value is 1 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include Maltol?

Maltol appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Australia; Food and drug - smoking-related products, IFRA Transparency, and 3 more. Source: EPA CPDat.

Is Maltol used in cosmetics?

Yes, Maltol is also indexed as a cosmetic ingredient under the name Maltol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Maltol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Maltol have different safety status in cosmetics vs industrial chemicals?

Maltol is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H341, H315, H319, H335).

Is Maltol used outside industrial chemicals?

Maltol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.