Danger GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

2,2'-Methylenebis(4-methyl-6-tert-butylphenol)

Also known as: 2,2'-Methanediylbis(6-tert-butyl-4-methylphenol), 4-06-00-06801, Alterungsschutzmittel BKF, Antioxidant NG-2246, AO 1 (+15 more)

CAS 119-47-1

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (CAS 119-47-1) is a chemical substance with GHS signal word Danger; key hazard signal: H360F. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Methylene Di-t-Butylcresol →

SOURCE NOAEL studies
NOAEL studies
38
SOURCE Chemical inventory jurisdictions
Regulatory lists
6
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)
CAS Number
119-47-1
Molecular Formula
C23H32O2
InChI Key
KGRVJHAUYBGFFP-UHFFFAOYSA-N
Monoisotopic Mass
340.24023
Synonyms
2,2'-Methanediylbis(6-tert-butyl-4-methylphenol)4-06-00-06801Alterungsschutzmittel BKFAntioxidant NG-2246AO 1Bisaklofen BPBRN 2062676p-Cresol, 2,2'-methylenebis(6-tert-butyl-Di(2-hydroxy-5-methyl-3-tert-butylphenyl)methaneEINECS 204-327-1Methane, 2,2'-bis(6-tert-butyl-p-cresyl)-Methylene bis methyl butyl phenol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Repr. 1BH360FGHS08Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 29 records
AntioxidantFragranceHeat stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
Europe; plastic_additiveEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
EuropeEuropean Chemicals AgencyEuropean Chemicals Agency (ECHA)
IFRA TransparencyIFRAIFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 38 of 38 studies
ValueUnitEndpointRouteSpeciesSource
17.36uMAC50--NTP ICE endocrine
37.18uMAC50--NTP ICE endocrine
15.59uMACC--NTP ICE endocrine
25.03uMACC--NTP ICE endocrine
22.4uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=1.25mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
KVM0X4X57BUNIIFDA UNII substance identifier--openFDA substances
2.140e-8fractionFu-HumanNTP ICE adme parameters
=6.6mg/kg bw/dayLOAELoralDogECHA
>=40mg/kg bw/dayLOAELoralRatECHA
=42.3mg/kg bw/dayLOAELoralRatECHA
=50mg/kg bw/dayLOAELoralRatECHA
=54.2mg/kg bw/dayLOAELoralRatECHA
<=60mg/kg bw/dayLOAELoralRatECHA
=75.65mg/kg bw/dayLOAELoralRatECHA
=88mg/kg bw/dayLOAELoralRatECHA
=113.2mg/kg bw/dayLOAELoralRatECHA
=200mg/kg bw/dayLOAELoralRatECHA
=345.4mg/kg bw/dayLOAELoralRatECHA
>=371mg/kg bw/dayLOAELoralMouseECHA
<=447mg/kg bw/dayLOAELoralMouseECHA
=618mg/kg bw/dayLOAELoralRatECHA
0unitlessModel Score--NTP ICE endocrine
0.00113unitlessModel Score--NTP ICE endocrine
0.234unitlessModel Score--NTP ICE endocrine
=4mg/kg bw/dayNOAELoralDogECHA
=12.5mg/kg bw/dayNOAELoralRatECHA
=12.7mg/kg bw/dayNOAELoralRatECHA
=15.1mg/kg bw/dayNOAELoralRatECHA
=24.91mg/kg bw/dayNOAELoralRatECHA
=31.3mg/kg bw/dayNOAELoralRatECHA
=50mg/kg bw/dayNOAELoralRatECHA
=54.2mg/kg bw/dayNOAELoralRatECHA
=104mg/kg bw/dayNOAELoralRatECHA
=113.2mg/kg bw/dayNOAELoralRatECHA
=800mg/kg bw/dayNOAELoralRatECHA
<0.12%NOELoralRatToxValDB HESS
=1.92mg/kg bw/dayNOELoralRatToxValDB HESS

Showing 38 of 38 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol204-327-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.5%
Category
Antioxidant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL460648
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (CAS 119-47-1) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360F. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) has 38 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) appears on 6 regulatory/inventory lists including Indirect additives food contact (10/2018), inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, and 3 more. Source: EPA CPDat.

Is 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) used in cosmetics?

Yes, 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is also indexed as a cosmetic ingredient under the name Methylene Di-t-Butylcresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) have different safety status in cosmetics vs industrial chemicals?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is classified GHS Danger (H360F) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

Is 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) used outside industrial chemicals?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) also appears in cosmetics, pharmaceutical databases.