Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Methylene Di-t-Butylcresol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 12.7 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 24.91 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 88 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 12.5 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 ppm | oral | dog | oral | REACH |
Expert Verdict
Classified as a potential endocrine disruptor; reproductive toxicity concerns flagged in some assessments. EU restricts concentration due to these concerns. Also known as BHT dimer / 2,2'-methylenebis(6-tert-butyl-4-methylphenol). A bisphenolic antioxidant that prevents oxidative degradation of oils, fats, and active ingredients. More effective than BHT alone in some applications due to its dimeric structure. Must comply with the 0.5% limit in the EU.
Regulatory Flags
Frequently Asked Questions
Is Methylene Di-t-Butylcresol safe in cosmetics?
Classified as a potential endocrine disruptor; reproductive toxicity concerns flagged in some assessments. EU restricts concentration due to these concerns. Also known as BHT dimer / 2,2'-methylenebis(6-tert-butyl-4-methylphenol). A bisphenolic antioxidant that prevents oxidative degradation of oils, fats, and active ingredients. More effective than BHT alone in some applications due to its dimeric structure. Must comply with the 0.5% limit in the EU. The EU classifies Methylene Di-t-Butylcresol as "restricted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is Methylene Di-t-Butylcresol allowed in the EU?
Methylene Di-t-Butylcresol EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Methylene Di-t-Butylcresol do in cosmetics?
Methylene Di-t-Butylcresol functions as: Antioxidant (stabilizer for oils, fats, and formulations). It is classified as a cosmetic ingredient in our database. CAS number: 119-47-1.
What is the Margin of Safety for Methylene Di-t-Butylcresol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methylene Di-t-Butylcresol?
The NOAEL (No Observed Adverse Effect Level) for Methylene Di-t-Butylcresol is 12.7 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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