What is the NOAEL for Ethylparaben?
Ethylparaben has 43 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ethylparaben
Also known as: ethyl 4-hydroxybenzoate, 4-10-00-00367, BRN 1101972, Carbethoxyphenol, Caswell No. 447 (+7 more)
CAS 120-47-8
Ethylparaben (CAS 120-47-8) is a chemical substance. Key regulatory status: REACH registered, 36 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Ethylparaben is classified GHS Danger (H304, H315, H317, H319, H401) in the chemicals database but is restricted in EU cosmetics at max 0.4% as acid in finished product; 0.8% cap for total paraben mixture.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
43
SOURCE
chemical inventory jurisdictions
Regulatory lists
36
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Ethylparaben
CAS Number
120-47-8
DTXSID
DTXSID9022528
Molecular Formula
C9H10O3
InChI Key
NUVBSKCKDOMJSU-UHFFFAOYSA-N
Monoisotopic Mass
166.062994
Synonyms
ethyl 4-hydroxybenzoate4-10-00-00367BRN 1101972CarbethoxyphenolCaswell No. 447EINECS 204-399-4EPA Pesticide Chemical Code 061202Ethyl p-oxybenzoateEster etylowykwasu p-hydroksybenzoesowegoEthylester kyseliny p-hydroxybenzoovep-OxybenzoesaeureaethylesterUNII-14255EXE39
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
PreservativeFragranceFlavouring and nutrientFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
36 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| children | Vermont Department of Health | State of Vermont |
| children | Maine Department of Environmental Protection | State of Maine |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| nondetect; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children | Oregon Health Authority | State of Oregon |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Personal care; Southeast Asia | Asean | ASEAN Cosmetics |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 43 of 43 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 26.8229513775814 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 100000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 111000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 12.7721629015894 | uM | ACC | - | - | NTP_ICE_endocrine |
| <=10 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| <=10 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| <=10 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 57.24 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 126 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =173 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 24800 | nM | EC50 | - | - | NTP_ICE_endocrine |
| 14255EXE39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14255EXE39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14255EXE39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14255EXE39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.1057 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.1275 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 39800 | nM | IC01 | - | - | NTP_ICE_endocrine |
| >3100 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4300 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =11000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =18 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =60 | mg/kg bw/day | LEL | injection | Mouse | ToxValDB_Uterotrophic_Hershberger_DB |
| =180 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =4000 | mg/kg bw/day | LOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| 180 | mg/kg bw/day | LOEL | Subcutaneous | Rat | NTP_ICE_endocrine |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0864 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >300 | mg/kg bw/day | NOAEL | oral | Hamster | ToxValDB_ECHA_IUCLID |
| >=900 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1000 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =1030 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1030 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1043 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1043 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =1043 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1043 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1043 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| <=1200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| 52 | % | Relative potency | - | - | NTP_ICE_endocrine |
| 98 | % | Uterine weight increase vs control | Subcutaneous | Rat | NTP_ICE_endocrine |
Showing 43 of 43 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethyl 4-hydroxybenzoate | 204-399-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.4% as acid in finished product; 0.8% cap for total paraben mixture
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ETHYLPARABEN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
14
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E214 — ADI: 10 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Ethylparaben?
Ethylparaben appears on 25 regulatory/inventory lists including active_ingredient; Europe; Pesticides, IFRA Transparency, Europe, and 22 more. Source: EPA CPDat.
Is Ethylparaben used in cosmetics?
Yes, Ethylparaben is also indexed as a cosmetic ingredient under the name Ethylparaben. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ethylparaben come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Ethylparaben have different safety status in cosmetics vs industrial chemicals?
Ethylparaben is classified GHS Danger (H304, H315, H317, H319, H401) in the chemicals database but is restricted in EU cosmetics at max 0.4% as acid in finished product; 0.8% cap for total paraben mixture.
Is Ethylparaben used outside industrial chemicals?
Ethylparaben also appears in cosmetics, pharmaceutical, food safety, cannabis databases.