What is the NOAEL for 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal?
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal has 23 NOAEL studies in the database. The lowest reported value is 1.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal
Also known as: 1,3-Benzodioxole-5-propanal, alpha-methyl-, 1,3-Benzodioxole-5-propanal, .alpha.-methyl-, alpha-Methyl-1,3-benzodioxole-5-propionaldehyde, Hydrocinnamaldehyde, alpha-methyl-3,4-(methylenedioxy)- (8CI), EINECS 214-881-6 (+5 more)
CAS 1205-17-0
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal (CAS 1205-17-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Methylenedioxyphenyl Methylpropanal (Helional) →
Cross-Vertical Regulatory Divergence
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal is classified GHS CMR hazard (H317, H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
23
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal
CAS Number
1205-17-0
DTXSID
DTXSID7043908
Molecular Formula
C11H12O3
InChI Key
BOPPSUHPZARXTH-UHFFFAOYSA-N
Monoisotopic Mass
192.078644
Synonyms
1,3-Benzodioxole-5-propanal, alpha-methyl-1,3-Benzodioxole-5-propanal, .alpha.-methyl-alpha-Methyl-1,3-benzodioxole-5-propionaldehydeHydrocinnamaldehyde, alpha-methyl-3,4-(methylenedioxy)- (8CI)EINECS 214-881-6a-Methyl-1,3-benzodioxole-5-propionaldehydeNSC 22282UNII-L65EG8H6PAOcean propanalalpha-Methyl-3,4-methylene-dioxyhydrocinnamic aldehyde
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 23 of 23 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 121.93 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 93.05 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 154 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =1.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 77.71 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 16.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 16.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 264.4 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| L65EG8H6PA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L65EG8H6PA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L65EG8H6PA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L65EG8H6PA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 710.4 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 9.89 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =300 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =50 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >300 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 23 of 23 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | α-methyl-1,3-benzodioxole-5-propionaldehyde | 214-881-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3183457
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal?
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency. Source: EPA CPDat.
Is 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal used in cosmetics?
Yes, 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal is also indexed as a cosmetic ingredient under the name Methylenedioxyphenyl Methylpropanal (Helional). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal have different safety status in cosmetics vs industrial chemicals?
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal is classified GHS CMR hazard (H317, H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Is 3-(3,4-Methylenedioxyphenyl)-2-methylpropanal used outside industrial chemicals?
3-(3,4-Methylenedioxyphenyl)-2-methylpropanal also appears in cosmetics, pharmaceutical databases.