Also known as: 1,3-Benzodioxole-5-propanal, alpha-methyl-, 1,3-Benzodioxole-5-propanal, .alpha.-methyl-, alpha-Methyl-1,3-benzodioxole-5-propionaldehyde, Hydrocinnamaldehyde, alpha-methyl-3,4-(methylenedioxy)- (8CI), EINECS 214-881-6 (+5 more)
INCI: METHYLENEDIOXYPHENYL METHYLPROPANAL
Methylenedioxyphenyl Methylpropanal (Helional) (CAS 1205-17-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (perfuming). Reported NOAEL =50 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1205-17-0 →
Methylenedioxyphenyl Methylpropanal (Helional) is classified GHS CMR hazard (H317, H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Methylenedioxyphenyl Methylpropanal (Helional).
Calculate MoS for your specific formulation with the MoS Calculator.
3 study endpoints found for Methylenedioxyphenyl Methylpropanal (Helional). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | dermal | Rat | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: Kern et al. (2010); DPRA: Hoffmann et al., 2018; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 109 | 0 | 11810 | 11810 | non-sensitizer |
| HRIPT | 115 | 0 | 4015 | 4015 | non-sensitizer |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Methylenedioxyphenyl Methylpropanal (Helional).
Public NOAEL study rows linked to Methylenedioxyphenyl Methylpropanal (Helional) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Methylenedioxyphenyl Methylpropanal (Helional) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Methylenedioxyphenyl Methylpropanal (Helional) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Methylenedioxyphenyl Methylpropanal (Helional) functions as: Fragrance ingredient (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 1205-17-0.
The NOAEL (No Observed Adverse Effect Level) for Methylenedioxyphenyl Methylpropanal (Helional) is =50 mg/kg bw/day based on a acute study via dermal route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Methylenedioxyphenyl Methylpropanal (Helional) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Methylenedioxyphenyl Methylpropanal (Helional) is classified GHS CMR hazard (H317, H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
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