NOAEL Data REACH Registered Cosmetic Ingredient

2-tert-Butyl-4-methoxyphenol

Also known as: 3-tert-Butyl-4-hydroxyanisole, Phenol, 2-(1,1-dimethylethyl)-4-methoxy-, Phenol, 2-tert-butyl-4-methoxy-, BRN 1867499, Butylated hydroxyanisole I (+13 more)

CAS 121-00-6

2-tert-Butyl-4-methoxyphenol (CAS 121-00-6) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 2-Tert-Butylhydroquinone Methyl Ether →

Cross-Vertical Regulatory Divergence

2-tert-Butyl-4-methoxyphenol is classified GHS CMR hazard (H315, H319, H351, H361, H411, H317, H371, H401) in the chemicals database but is restricted in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields

Name

2-tert-Butyl-4-methoxyphenol

CAS Number

121-00-6

DTXSID

DTXSID7040788

Molecular Formula

C11H16O2

InChI Key

MRBKEAMVRSLQPH-UHFFFAOYSA-N

Monoisotopic Mass

180.11503

Synonyms

3-tert-Butyl-4-hydroxyanisolePhenol, 2-(1,1-dimethylethyl)-4-methoxy-Phenol, 2-tert-butyl-4-methoxy-BRN 1867499Butylated hydroxyanisole I2-Butyl-4-hydroxyanisole2-(1,1-Dimethylethyl)-4-methoxy-phenolEINECS 204-442-7UNII-62RAC242922-(1,1-dimethylethyl)-4-methoxyphenol3-(1,1-dimethylethyl)-4-hydroxyanisole3-BHA

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
Europe; Food contact items	Danish Environmental Protection Agency	Danish EPA
drinking_water; Europe; soil	Danish Environmental Protection Agency	Danish EPA
children; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods; Toys and children's products	Danish EPA	Danish EPA
Europe; nondetect; Other direct contact consumer goods; Toys and children's products	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 48 of 48 studies

Value	Unit	Endpoint	Route	Species	Source
53.0811678218426	uM	AC50	-	-	NTP_ICE_endocrine
34.3137252443965	uM	ACC	-	-	NTP_ICE_endocrine
7.06	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=3.112	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
=4.93	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
62RAC24292	UNII	FDA UNII substance identifier	-	-	openFDA substances
62RAC24292	UNII	FDA UNII substance identifier	-	-	openFDA substances
62RAC24292	UNII	FDA UNII substance identifier	-	-	openFDA substances
62RAC24292	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.07217	fraction	Fu	-	Human	NTP_ICE_adme_parameters
=2910	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=50	mg/kg bw/day	LOAEL	injection	Rat	ToxValDB_ECHA_IUCLID
=100	mg/kg bw/day	LOAEL	oral	Hamster	ToxValDB_ECHA_IUCLID
=300	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
~750	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
~125	mg/kg bw/day	LOEL	oral	Monkey	ToxValDB_ECHA_IUCLID
=700	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=3300	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=9900	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=12600	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=14000	mg/kg bw/day	LOEL	oral	Monkey	ToxValDB_ECHA_IUCLID
=15000	mg/kg bw/day	LOEL	oral	Monkey	ToxValDB_ECHA_IUCLID
=24500	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=30000	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=35000	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=36000	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=63000	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.0139	unitless	Model Score	-	-	NTP_ICE_endocrine
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<55	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=120	mg/kg bw/day	NOAEL	oral	Hamster	ToxValDB_ECHA_IUCLID
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=225	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
~230	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
~250	mg/kg bw/day	NOAEL	oral	Monkey	ToxValDB_ECHA_IUCLID
=400	mg/kg bw/day	NOAEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
~500	mg/kg bw/day	NOAEL	oral	Monkey	ToxValDB_ECHA_IUCLID
~925	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
<936	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<1200	mg/kg bw/day	NOAEL	oral	Hamster	ToxValDB_ECHA_IUCLID
=10	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
>50	mg/kg bw/day	NOEL	oral	Pig	ToxValDB_ECHA_IUCLID
=350	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=750	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 48 of 48 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-tert-butyl-4-methoxyphenol	204-442-7	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-tert-Butyl-4-methoxyphenol?

2-tert-Butyl-4-methoxyphenol has 48 NOAEL studies in the database. The lowest reported value is 0.07217 fraction in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 2-tert-Butyl-4-methoxyphenol?

2-tert-Butyl-4-methoxyphenol appears on 7 regulatory/inventory lists including IFRA Transparency, detected; drinking_water; MN Chemical Screening, Indirect additives food contact (10/2018), and 4 more. Source: EPA CPDat.

Is 2-tert-Butyl-4-methoxyphenol used in cosmetics?

Yes, 2-tert-Butyl-4-methoxyphenol is also indexed as a cosmetic ingredient under the name 2-Tert-Butylhydroquinone Methyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-tert-Butyl-4-methoxyphenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-tert-Butyl-4-methoxyphenol have different safety status in cosmetics vs industrial chemicals?

2-tert-Butyl-4-methoxyphenol is classified GHS CMR hazard (H315, H319, H351, H361, H411, H317, H371, H401) in the chemicals database but is restricted in EU cosmetics.

Is 2-tert-Butyl-4-methoxyphenol used outside industrial chemicals?

2-tert-Butyl-4-methoxyphenol also appears in cosmetics, cannabis databases.