NOAEL Data REACH Registered Cosmetic Ingredient

2-tert-Butyl-4-methoxyphenol

Also known as: 3-tert-Butyl-4-hydroxyanisole, Phenol, 2-​(1,​1-​dimethylethyl)​-​4-​methoxy-, Phenol, 2-tert-butyl-4-methoxy-, BRN 1867499, Butylated hydroxyanisole I (+13 more)

CAS 121-00-6

2-tert-Butyl-4-methoxyphenol (CAS 121-00-6) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 2-Tert-Butylhydroquinone Methyl Ether →

SOURCE NOAEL studies
NOAEL studies
45
SOURCE Chemical inventory jurisdictions
Regulatory lists
8
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields
Name
2-tert-Butyl-4-methoxyphenol
CAS Number
121-00-6
Molecular Formula
C11H16O2
InChI Key
MRBKEAMVRSLQPH-UHFFFAOYSA-N
Monoisotopic Mass
180.11503
Synonyms
3-tert-Butyl-4-hydroxyanisolePhenol, 2-​(1,​1-​dimethylethyl)​-​4-​methoxy-Phenol, 2-tert-butyl-4-methoxy-BRN 1867499Butylated hydroxyanisole I2-Butyl-4-hydroxyanisole2-(1,1-Dimethylethyl)-4-methoxy-phenolEINECS 204-442-7UNII-62RAC242922-(1,1-dimethylethyl)-4-methoxyphenol3-(1,1-dimethylethyl)-4-hydroxyanisole3-BHA

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Europe; Food contact itemsDanish Environmental Protection AgencyDanish EPA
drinking_water; Europe; soilDanish Environmental Protection AgencyDanish EPA
children; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; nondetect; Other direct contact consumer goods; Toys and children's productsDanish EPADanish EPA
Europe; nondetect; Other direct contact consumer goods; Toys and children's productsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 45 of 45 studies
ValueUnitEndpointRouteSpeciesSource
53.08uMAC50--NTP ICE endocrine
34.31uMACC--NTP ICE endocrine
7.06uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
=3.112mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
=4.93mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
62RAC24292UNIIFDA UNII substance identifier--openFDA substances
0.07217fractionFu-HumanNTP ICE adme parameters
=2910mg/kg bwLD50oralRatNTP ICE acute oral
=4000mg/kg bwLD50oralRatNTP ICE acute oral
=50mg/kg bw/dayLOAELinjectionRatECHA
=100mg/kg bw/dayLOAELoralHamsterECHA
=300mg/kg bw/dayLOAELoralRatECHA
=500mg/kg bw/dayLOAELoralMouseECHA
~750mg/kg bw/dayLOAELoralMouseECHA
~125mg/kg bw/dayLOELoralMonkeyECHA
=700mg/kg bw/dayLOELoralRatECHA
=3300mg/kg bw/dayLOELoralRatECHA
=9900mg/kg bw/dayLOELoralRatECHA
=1.260e+4mg/kg bw/dayLOELoralMouseECHA
=1.400e+4mg/kg bw/dayLOELoralMonkeyECHA
=1.500e+4mg/kg bw/dayLOELoralMonkeyECHA
=2.450e+4mg/kg bw/dayLOELoralRatECHA
=3.000e+4mg/kg bw/dayLOELoralRatECHA
=3.500e+4mg/kg bw/dayLOELoralRatECHA
=3.600e+4mg/kg bw/dayLOELoralRatECHA
=6.300e+4mg/kg bw/dayLOELoralRatECHA
0unitlessModel Score--NTP ICE endocrine
0.0139unitlessModel Score--NTP ICE endocrine
=50mg/kg bw/dayNOAELoralRatECHA
<55mg/kg bw/dayNOAELoralRatECHA
=120mg/kg bw/dayNOAELoralHamsterECHA
=200mg/kg bw/dayNOAELoralRatECHA
=225mg/kg bw/dayNOAELoralMouseECHA
~230mg/kg bw/dayNOAELoralRatECHA
~250mg/kg bw/dayNOAELoralMonkeyECHA
=400mg/kg bw/dayNOAELoralRabbitECHA
~500mg/kg bw/dayNOAELoralMonkeyECHA
~925mg/kg bw/dayNOAELoralMouseECHA
<936mg/kg bw/dayNOAELoralRatECHA
<1000mg/kg bw/dayNOAELoralRatECHA
<1200mg/kg bw/dayNOAELoralHamsterECHA
=10mg/kg bw/dayNOELoralRatECHA
>50mg/kg bw/dayNOELoralPigECHA
=350mg/kg bw/dayNOELoralRatECHA
=750mg/kg bw/dayNOELoralRatECHA

Showing 45 of 45 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered2-tert-butyl-4-methoxyphenol204-442-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-tert-Butyl-4-methoxyphenol?

2-tert-Butyl-4-methoxyphenol has 45 NOAEL studies in the database. The lowest reported value is 0.07217 fraction in Human. Source: NTP ICE adme parameters.

What regulatory lists include 2-tert-Butyl-4-methoxyphenol?

2-tert-Butyl-4-methoxyphenol appears on 7 regulatory/inventory lists including IFRA Transparency, detected; drinking_water; MN Chemical Screening, Indirect additives food contact (10/2018), and 4 more. Source: EPA CPDat.

Is 2-tert-Butyl-4-methoxyphenol used in cosmetics?

Yes, 2-tert-Butyl-4-methoxyphenol is also indexed as a cosmetic ingredient under the name 2-Tert-Butylhydroquinone Methyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-tert-Butyl-4-methoxyphenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-tert-Butyl-4-methoxyphenol have different safety status in cosmetics vs industrial chemicals?

2-tert-Butyl-4-methoxyphenol is classified GHS CMR hazard (H315, H319, H351, H361, H411, H317, H371, H401) in the chemicals database but is restricted in EU cosmetics.

Is 2-tert-Butyl-4-methoxyphenol used outside industrial chemicals?

2-tert-Butyl-4-methoxyphenol also appears in cosmetics, cannabis databases.