2-Tert-Butylhydroquinone Methyl Ether
INCI: 2-TERT-BUTYLHYDROQUINONE METHYL ETHER
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2-Tert-Butylhydroquinone Methyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOEL | 63000 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 154.8519 other | 1991 | rat | inhalation | REACH |
| LOEL | 9900 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 3300 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 14000 mg/kg bw/day | oral | monkey | oral | REACH |
| LOEL | 700 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 10900 other | oral | mouse | oral | REACH |
| LOEL | 15000 mg/kg bw/day | oral | monkey | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 50 mg/kg bw/day | 2400 | rat | other | REACH |
Expert Verdict
Structural relationship to TBHQ — monitor for potential oxidative metabolites. Not the same as TBHQ itself but deserves attention.
Regulatory Flags
Frequently Asked Questions
Is 2-Tert-Butylhydroquinone Methyl Ether safe in cosmetics?
Structural relationship to TBHQ — monitor for potential oxidative metabolites. Not the same as TBHQ itself but deserves attention. The EU classifies 2-Tert-Butylhydroquinone Methyl Ether as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is 2-Tert-Butylhydroquinone Methyl Ether allowed in the EU?
2-Tert-Butylhydroquinone Methyl Ether EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Tert-Butylhydroquinone Methyl Ether do in cosmetics?
2-Tert-Butylhydroquinone Methyl Ether functions as: Fragrance; Fragrance Functional (excipient). It is classified as a cosmetic ingredient in our database. CAS number: 121-00-6.
What is the Margin of Safety for 2-Tert-Butylhydroquinone Methyl Ether?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Tert-Butylhydroquinone Methyl Ether?
The NOAEL (No Observed Adverse Effect Level) for 2-Tert-Butylhydroquinone Methyl Ether is 63000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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