Warning GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Propyl gallate

Also known as: PG, Gallic acid n-propyl ester, Gallic acid, propyl ester, Benzoic acid, 3,4,5-trihydroxy-, propyl ester, EINECS 204-498-2 (+6 more)

CAS 121-79-9

Propyl gallate (CAS 121-79-9) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H317; H400; H410. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Propyl Gallate →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

Propyl gallate

CAS Number

121-79-9

DTXSID

DTXSID5021201

Molecular Formula

C10H12O5

InChI Key

ZTHYODDOHIVTJV-UHFFFAOYSA-N

Monoisotopic Mass

212.068473

Synonyms

PGGallic acid n-propyl esterGallic acid, propyl esterBenzoic acid, 3,4,5-trihydroxy-, propyl esterEINECS 204-498-2FEMA No. 2947NCI-C5058883,4,5-Trihydroxybenzene-1-propylcarboxylate3,4,5-Trihydroxybenzoic acid n-propyl esterPropylester kyseliny galloveUNII-8D4SNN7V92

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1	H302; H317; H400; H410	GHS07; GHS09	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 42 records

AntioxidantFragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
animal_products	USDA	United States Department of Agriculture (USDA)
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 93 studies

Value	Unit	Endpoint	Route	Species	Source
30.4262745677929	uM	AC50	-	-	NTP ICE endocrine
18.456602161568	uM	ACC	-	-	NTP ICE endocrine
=0.5	mg/kg bw/day	ADI	-	Consumers	EFSA
=0.5	mg/kg bw/day	ADI	-	Consumers	EFSA
<=1.4	mg/kg	ADI	oral	Human	WHO/JECFA
0.69	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
10	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
20.19	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
23.77	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
26.369	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
29.29	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
32.4	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
32.5	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
1.74	ug/mL	CD86, EC120	Dermal	-	NTP ICE skin sensitization
1.889	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
1.97	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
32.75	ug/mL	CV70	Dermal	-	NTP ICE skin sensitization
14.8	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
125	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
49.7	uL/min/10^6 cells	Clint	-	Human	NTP ICE adme parameters
=6.66	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
24.8	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
59.2	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
59.9	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
-303	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
26.6	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
63.6	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
12	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
43.25	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
61.4	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
132.8	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
>140	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
191	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
199.8	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
202.727	uM	EC3	Dermal	-	NTP ICE skin sensitization
8D4SNN7V92	UNII	FDA UNII substance identifier	-	-	openFDA substances
8D4SNN7V92	UNII	FDA UNII substance identifier	-	-	openFDA substances
8D4SNN7V92	UNII	FDA UNII substance identifier	-	-	openFDA substances
8D4SNN7V92	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.0258	fraction	Fu	-	Human	NTP ICE adme parameters
605	uM	IC50	Dermal	-	NTP ICE skin sensitization
650.3	uM	IC50	Dermal	-	NTP ICE skin sensitization
731.5	uM	IC50	Dermal	-	NTP ICE skin sensitization
0.8886	ratio	Imax	Dermal	-	NTP ICE skin sensitization
8.2	ratio	Imax	Dermal	-	NTP ICE skin sensitization
8.68	ratio	Imax	Dermal	-	NTP ICE skin sensitization
9.24	ratio	Imax	Dermal	-	NTP ICE skin sensitization
=300	mg/kg bw/day	LEL	oral	Rat	ToxValDB ToxRefDB
=300	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	EPA ToxRefDB v3
=900	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB

Showing 50 of 93 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Propyl 3,4,5-trihydroxybenzoate	204-498-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed PROPYL GALLATE

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Propyl gallate?

Propyl gallate (CAS 121-79-9) is classified under EU CLP Annex VI as Acute Tox. 4; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H302; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Propyl gallate?

Propyl gallate has 93 NOAEL studies in the database. The lowest reported value is -303 % via Dermal. Source: NTP ICE skin sensitization.

What regulatory lists include Propyl gallate?

Propyl gallate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, animal_products, IFRA Transparency, and 3 more. Source: EPA CPDat.

Is Propyl gallate used in cosmetics?

Yes, Propyl gallate is also indexed as a cosmetic ingredient under the name Propyl Gallate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Propyl gallate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Propyl gallate used outside industrial chemicals?

Propyl gallate also appears in cosmetics, pharmaceutical, cannabis databases.