Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Propyl Gallate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1500 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 3750 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1875 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| NOAEL | 900 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
Expert Verdict
Confirmed dermal sensitizer and skin/eye irritant; inhalation hazard; some studies flag possible estrogenic activity; requires careful concentration management
Regulatory Flags
Frequently Asked Questions
Is Propyl Gallate safe in cosmetics?
Confirmed dermal sensitizer and skin/eye irritant; inhalation hazard; some studies flag possible estrogenic activity; requires careful concentration management The EU classifies Propyl Gallate as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Propyl Gallate allowed in the EU?
Propyl Gallate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propyl Gallate do in cosmetics?
Propyl Gallate functions as: Antioxidant, Perfuming agent. It is classified as a cosmetic ingredient in our database. CAS number: 121-79-9.
What is the Margin of Safety for Propyl Gallate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Propyl Gallate?
The NOAEL (No Observed Adverse Effect Level) for Propyl Gallate is 1500 mg/kg bw/day based on a Chronic study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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