What is the NOAEL for 1,3-Benzenedicarboxylic acid?
1,3-Benzenedicarboxylic acid has 16 NOAEL studies in the database. The lowest reported value is 1.44 uL/min/10^6 cells in Rat. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Benzenedicarboxylic acid
Also known as: Isophthalic acid, 3-Carboxybenzoic acid, Isoterephthalic acid, 4-09-00-03292, BRN 1909332 (+4 more)
CAS 121-91-5
1,3-Benzenedicarboxylic acid (CAS 121-91-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
1,3-Benzenedicarboxylic acid
CAS Number
121-91-5
DTXSID
DTXSID3021485
Molecular Formula
C8H6O4
InChI Key
QQVIHTHCMHWDBS-UHFFFAOYSA-N
Monoisotopic Mass
166.026609
Synonyms
Isophthalic acid3-Carboxybenzoic acidIsoterephthalic acid4-09-00-03292BRN 1909332EINECS 204-506-4Kyselina isoftalovaUNII-X35216H9FJmeta-benzenedicarboxylic acid
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
| Short-term Effects | May cause mechanical irritation to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
SolventNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1.44 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =8.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| X35216H9FJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X35216H9FJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X35216H9FJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X35216H9FJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >11.37 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =10400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =10900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =12200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =13000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =9.07 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =9.59 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >10 | mg/m3 | NOAEL | Inhalation | Rat | ToxValDB_HPVIS |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isophthalic acid | 204-506-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISOPHTHALIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include 1,3-Benzenedicarboxylic acid?
1,3-Benzenedicarboxylic acid appears on 4 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, CEDI, and 1 more. Source: EPA CPDat.
Is 1,3-Benzenedicarboxylic acid used in cosmetics?
Yes, 1,3-Benzenedicarboxylic acid is also indexed as a cosmetic ingredient under the name ISOPHTHALIC ACID. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Benzenedicarboxylic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,3-Benzenedicarboxylic acid used outside industrial chemicals?
1,3-Benzenedicarboxylic acid also appears in cosmetics, pharmaceutical databases.