Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Ammonium chloride

Also known as: (NH4)Cl, Ammonium chloride ((NH4)​Cl), A649-3, Amoklor, Darvan 20 (+15 more)

CAS 12125-02-9

Ammonium chloride (CAS 12125-02-9) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Ammonium Chloride →

SOURCE noael studies public
NOAEL studies
18
SOURCE chemical inventory jurisdictions
Regulatory lists
18
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Ammonium chloride
CAS Number
12125-02-9
DTXSID
DTXSID0020078
Molecular Formula
ClH.H3N
InChI Key
NLXLAEXVIDQMFP-UHFFFAOYSA-N
Monoisotopic Mass
53.003227
Synonyms
(NH4)ClAmmonium chloride ((NH4)​Cl)A649-3AmoklorDarvan 20SalammoniacusSalmiacumAmmon ChlorAmmonii ChloridumAmmonium ChloratumAmmonium Chloride InjectionAmmonium Chloride Tablets

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Eye Irrit. 2H302; H319GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract.
Routes of ExposureThe substance can be absorbed into the body by inhalation of dust or fume and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records
AgencyMetricValueppmmg/m3Skin
NIOSHTWA10 mg/m³-10N
NIOSHSTEL20 mg/m³-20N
ACGIHTWA10 mg/m³ [1970]-10N
ACGIHSTEL20 mg/m³ [1970]-20N
CAL/OSHATWA10 mg/m³-10N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
pH regulating agentDeodorizerViscosity modifierThickening agentFragranceFlavouring and nutrientBiocideSoil amendmentsDispersing agentChelating agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records
ListKeywordSource
inert_ingredient; PesticidesEPACPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
EuropeEuropean CommissionFl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
fracking; waterNY Department of ConservationCPCat
frackingFracFocusFracFocus

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 18 of 18 studies
ValueUnitEndpointRouteSpeciesSource
=33.5mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
=43.97mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
01Q9PC255DUNIIFDA UNII substance identifier--openFDA substances
01Q9PC255DUNIIFDA UNII substance identifier--openFDA substances
01Q9PC255DUNIIFDA UNII substance identifier--openFDA substances
01Q9PC255DUNIIFDA UNII substance identifier--openFDA substances
=10000mg/kg bw/dayLELoralSheepToxValDB_EFSA
=15000mg/kg bw/dayLELoralSheepToxValDB_EFSA
200mg/kg bw/dayNOAELoraldogCOSMOS_DB
253mg/kg bw/dayNOAELoralcattleCOSMOS_DB
500mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
700mg/kg bw/dayNOAELoralratCOSMOS_DB
750mg/kg bw/dayNOAELoralratCOSMOS_DB
1000mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
1050mg/kg bw/dayNOAELoralratCOSMOS_DB
1500mg/kg bw/dayNOAELoralratCOSMOS_DB
2000mg/kg bw/dayNOAELoralcatCOSMOS_DB
=684mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 18 of 18 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredAmmonium chloride235-186-4ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL AMMONIUM CHLORIDE
ChEMBL Phase
4
Adverse Events
778
Bioactivity
0
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E510 — ADI: NOT LIMITED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ammonium chloride?

Ammonium chloride (CAS 12125-02-9) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ammonium chloride?

Ammonium chloride has 18 NOAEL studies in the database. The lowest reported value is 33.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Ammonium chloride?

Ammonium chloride appears on 9 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; Pesticides, and 6 more. Source: EPA CPDat.

What are the occupational exposure limits for Ammonium chloride?

Occupational exposure limits for Ammonium chloride are set by NIOSH, ACGIH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Ammonium chloride used in cosmetics?

Yes, Ammonium chloride is also indexed as a cosmetic ingredient under the name Ammonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ammonium chloride come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Ammonium chloride used outside industrial chemicals?

Ammonium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.