Is Ammonium Chloride safe in cosmetics?
Ammonium Chloride has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Ammonium Chloride
Also known as: (NH4)Cl, Ammonium chloride ((NH4)Cl), A649-3, Amoklor, Darvan 20 (+15 more)
INCI: AMMONIUM CHLORIDE
Ammonium Chloride (CAS 12125-02-9) is a cosmetic cosmetic ingredient functioning as Buffering, fragrance, viscosity controlling. NOAEL 684 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 12125-02-9 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering, fragrance, viscosity controlling
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific FDA restriction for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ammonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of dust or fume and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ammonium Chloride across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Eye Irrit. 2
Hazard Statements
- H302 Harmful if swallowed
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Chelating agent
Deodorizer
Dispersing agent
Filler
Flavouring and nutrient
Fragrance
Leavening agent
Processing aids not otherwise specified
Soil amendments
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Ammonium Chloride.
Regulatory Flags
fragrance-component
endocrine_disruptor
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ammonium Chloride by CAS number or substance name.
Studies
15
Lowest NOAEL
206 mg/kg bw/day
Highest NOAEL
768.5 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
(NH4)Cl
Ammonium chloride ((NH4)Cl)
A649-3
Amoklor
Darvan 20
Salammoniacus
Salmiacum
Ammon Chlor
Ammonii Chloridum
Ammonium Chloratum
Ammonium Chloride Injection
Ammonium Chloride Tablets
EINECS 235-186-4
Gen-Diur
Muriate of Ammonia
Sal ammonia
Salammonite
Ammonchlor
Ammoniumklorid
Chlorammonic
Chemical Function
pH regulating agent
Deodorizer
Viscosity modifier
Thickening agent
Fragrance
Flavouring and nutrient
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
fracking; water
fracking
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMMONIUM CHLORIDE
ChEMBL ID
CHEMBL1200939
Max Phase
4
Adverse Event Associations
778
Frequently Asked Questions
Is Ammonium Chloride allowed in the EU?
Ammonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Chloride do in cosmetics?
Ammonium Chloride functions as: Buffering, fragrance, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 12125-02-9.
Is Ammonium Chloride used outside cosmetics?
Ammonium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ammonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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