Good Cosmetic Ingredient NOAEL Data GHS Classified

Ammonium Chloride

INCI: AMMONIUM CHLORIDE

CAS Number
12125-02-9
Function
Buffering, fragrance, viscosity controlling
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no specific FDA restriction for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Ammonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2000 mg/kg bw/day oral cat Subchronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rabbit Short Term Toxicity COSMOS_DB
NOAEL 750 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 200 mg/kg bw/day oral dog Short Term Toxicity COSMOS_DB
NOAEL 700 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 700 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 750 mg/kg bw/day oral rabbit Short Term Toxicity COSMOS_DB
NOAEL 500 mg/kg bw/day oral rabbit Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of dust or fume and by ingestion.

Expert Verdict

Causes serious eye irritation (H319) and is harmful if swallowed (H302); eye-area formulations require careful concentration control.

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component endocrine_disruptor fda_food_additive jecfa_safe

Frequently Asked Questions

Is Ammonium Chloride safe in cosmetics?

Causes serious eye irritation (H319) and is harmful if swallowed (H302); eye-area formulations require careful concentration control. The EU classifies Ammonium Chloride as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Ammonium Chloride allowed in the EU?

Ammonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ammonium Chloride do in cosmetics?

Ammonium Chloride functions as: Buffering, fragrance, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 12125-02-9.

What is the Margin of Safety for Ammonium Chloride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ammonium Chloride?

The NOAEL (No Observed Adverse Effect Level) for Ammonium Chloride is 2000 mg/kg bw/day based on a Subchronic study via oral route in cat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Ammonium Chloride compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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