NOAEL Data Cosmetic Ingredient

Alpha-Amyl cinnamaldehyde

Also known as: alpha- Amyl cinnamal, 2-(Phenylmethylene)heptanal, 2-Benzylideneheptanal, Pentylcinnamaldehyde, 2-(Phenylmethylene)-heptanal (+15 more)

CAS 122-40-7

Alpha-Amyl cinnamaldehyde (CAS 122-40-7) is a chemical substance. Key regulatory status: 25 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Amyl Cinnamal →

SOURCE NOAEL studies
NOAEL studies
59
SOURCE Chemical inventory jurisdictions
Regulatory lists
25
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Alpha-Amyl cinnamaldehyde
CAS Number
122-40-7
Molecular Formula
C14H18O
InChI Key
HMKKIXGYKWDQSV-UHFFFAOYSA-N
Monoisotopic Mass
202.135765
Synonyms
alpha- Amyl cinnamal2-(Phenylmethylene)heptanal2-BenzylideneheptanalPentylcinnamaldehyde2-(Phenylmethylene)-heptanalHeptanal, 2-(phenylmethylene)-2-07-00-00310Amyl cinnamic aldehydeAmylcinnamalAmylcinnamaldehydeAmylcinnamic acid aldehydealpha-Amyl cinnamicaldehyde

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
FragranceDeodorizerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 25 records
ListKeywordSource
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
EuropeDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
IFRA TransparencyIFRAIFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
EuropeEuropean CommissionFl@vis
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshenerDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - general moisturizing - hand/body lotionDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; detected; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - dishwasher and dishes; Cleaning products and household care - general household cleaning - surface cleaner; detected; EuropeDanish Environmental Protection AgencyDanish EPA
consumer_product; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; EuropeDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - deodorantDanish Environmental Protection AgencyDanish EPA
Cleaning products and household care - laundry and fabric treatment - laundry detergent; EuropeDanish EPADanish EPA
Cleaning products and household care; EuropeDanish EPADanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng
inert_ingredient; non_food_use; PesticidesEPACPCat
consumer_productP&GProctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 59 studies
ValueUnitEndpointRouteSpeciesSource
32.76uMAC50--NTP ICE endocrine
50.29uMACC--NTP ICE endocrine
range:0-0.020.02mg/kg bw/dayADI--WHO/JECFA
range:0-0.50.5mg/kg bw/dayADIoral-WHO/JECFA
25.94ug/mLCD54, EC200Dermal-NTP ICE skin sensitization
13.13ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
24.9ug/mLCD86, EC150Dermal-NTP ICE skin sensitization
27.48ug/mLCV70Dermal-NTP ICE skin sensitization
24.2ug/mLCV75Dermal-NTP ICE skin sensitization
0.6%Depletion CysDermal-NTP ICE skin sensitization
3.9%Depletion LysDermal-NTP ICE skin sensitization
2.25%Depletion Lys + CysDermal-NTP ICE skin sensitization
14.4uMEC1.5Dermal-NTP ICE skin sensitization
>2000uMEC1.5Dermal-NTP ICE skin sensitization
10.6%EC3DermalMouseNTP ICE skin sensitization
>2000uMEC3Dermal-NTP ICE skin sensitization
WC51CA3418UNIIFDA UNII substance identifier--openFDA substances
46.77uMIC50Dermal-NTP ICE skin sensitization
51uMIC50Dermal-NTP ICE skin sensitization
1.57ratioImaxDermal-NTP ICE skin sensitization
0%Incidence of positive responsesDermalHumanNTP ICE skin sensitization
3724ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
3888ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
2.362e+4ug/cm2Induction dose per skin areaDermalHumanNTP ICE skin sensitization
=0.00005mg/m3LOAELinhalation-WHO/JECFA
=0.0004mg/m3LOAEL-HumanWHO/JECFA
=0.00066mg/gLOAEL-MouseWHO/JECFA
=0.00071mg/gLOAEL-MouseWHO/JECFA
=0.002mg/m3LOAEL--WHO/JECFA
=0.08mg/kg bw/dayLOAEL--WHO/JECFA
=0.19mg/kg bw/dayLOAEL--WHO/JECFA
=0.2mg/kg bw/dayLOAEL-RatWHO/JECFA
=0.5mg/LLOAELoralMouseWHO/JECFA
=1.4mg/LLOAEL-MouseWHO/JECFA
=5mg/LLOAELoralMouseWHO/JECFA
=6mg/m3LOAEL--WHO/JECFA
=512mg/LLOAEL--WHO/JECFA
=1036mg/LLOAEL--WHO/JECFA
=30%LOELdermalMouseToxValDB ECOTOX
0unitlessModel Score--NTP ICE endocrine
0.00842unitlessModel Score--NTP ICE endocrine
=0.00000337mg/m3NOAEL--WHO/JECFA
<0.00005mg/m3NOAEL-HumanWHO/JECFA
=0.0000529mg/m3NOAEL--WHO/JECFA
=0.0000847mg/gNOAELdermalMouseWHO/JECFA
=0.04mg/kg bw/dayNOAEL--WHO/JECFA
=0.25mg/LNOAEL-MouseWHO/JECFA
=0.5mg/LNOAEL-MouseWHO/JECFA
=2.5mg/LNOAELoralMouseWHO/JECFA
6mg/kg bw/dayNOAELoralratCOSMOS DB

Showing 50 of 59 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%
Category
fragrance
View full cosmetic safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Alpha-Amyl cinnamaldehyde?

Alpha-Amyl cinnamaldehyde has 59 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Alpha-Amyl cinnamaldehyde?

Alpha-Amyl cinnamaldehyde appears on 18 regulatory/inventory lists including Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe, Europe, Canada; pharmaceutical, and 15 more. Source: EPA CPDat.

Is Alpha-Amyl cinnamaldehyde used in cosmetics?

Yes, Alpha-Amyl cinnamaldehyde is also indexed as a cosmetic ingredient under the name Amyl Cinnamal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Alpha-Amyl cinnamaldehyde come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Alpha-Amyl cinnamaldehyde used outside industrial chemicals?

Alpha-Amyl cinnamaldehyde also appears in cosmetics, cannabis databases.