Amyl Cinnamal
INCI: AMYL CINNAMAL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Amyl Cinnamal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 6 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 6 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 23 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Amyl Cinnamal based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Dermal Penetration Profile
Skin absorption and penetration characteristics of Amyl Cinnamal, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
One of the eight fragrance allergens in Fragrance Mix I (FM I) used in standard patch testing. EU Annex III listed; mandatory labeling in leave-on cosmetics above 0.001% and rinse-off above 0.01%. Sensitization potential confirmed; concentration management per IFRA standards is the primary risk-mitigation strategy.
Regulatory Flags
Frequently Asked Questions
Is Amyl Cinnamal safe in cosmetics?
One of the eight fragrance allergens in Fragrance Mix I (FM I) used in standard patch testing. EU Annex III listed; mandatory labeling in leave-on cosmetics above 0.001% and rinse-off above 0.01%. Sensitization potential confirmed; concentration management per IFRA standards is the primary risk-mitigation strategy. The EU classifies Amyl Cinnamal as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Amyl Cinnamal allowed in the EU?
Amyl Cinnamal EU regulatory status: restricted. Maximum allowed concentration: Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%. This is based on EU Regulation 1223/2009 and its amendments.
What does Amyl Cinnamal do in cosmetics?
Amyl Cinnamal functions as: Fragrance. It is classified as a Fragrance in our database. CAS number: 122-40-7.
What is the Margin of Safety for Amyl Cinnamal?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Amyl Cinnamal?
The NOAEL (No Observed Adverse Effect Level) for Amyl Cinnamal is 300 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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