What is the NOAEL for Phenoxyacetic acid?
Phenoxyacetic acid has 7 NOAEL studies in the database. The lowest reported value is YRC253429Q UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Phenoxyacetic acid
Also known as: POA, 4-06-00-00634, BRN 0907949, EINECS 204-556-7, FEMA No. 2872 (+9 more)
CAS 122-59-8
Phenoxyacetic acid (CAS 122-59-8) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Phenoxyacetic acid
CAS Number
122-59-8
Molecular Formula
C8H8O3
InChI Key
LCPDWSOZIOUXRV-UHFFFAOYSA-N
Monoisotopic Mass
152.047344
Synonyms
POA4-06-00-00634BRN 0907949EINECS 204-556-7FEMA No. 2872Glycollic acid phenyl ethero-Phenylglycolic acidPhenylglycolic acid, O-UNII-YRC253429QPhenyl ether glycolic acid2-phenoxyethanoic acidGlycol acid phenyl ether
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| YRC253429Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =1500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| 250 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 800 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL173521
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phenoxyacetic acid?
Phenoxyacetic acid appears on 2 regulatory/inventory lists including Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Phenoxyacetic acid used in cosmetics?
Yes, Phenoxyacetic acid is also indexed as a cosmetic ingredient under the name Phenoxyacetic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenoxyacetic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenoxyacetic acid used outside industrial chemicals?
Phenoxyacetic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.