Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Phenoxyacetic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 800 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 800 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
Expert Verdict
GHS hazards include H302 (harmful if swallowed), H315 (skin irritation), H319 (serious eye irritation), and H335 (respiratory irritation). Classified for acute oral toxicity Category 4. Must be used at low concentrations in cosmetics with pH-dependent activity more pronounced at lower pH values.
Regulatory Flags
Frequently Asked Questions
Is Phenoxyacetic Acid safe in cosmetics?
GHS hazards include H302 (harmful if swallowed), H315 (skin irritation), H319 (serious eye irritation), and H335 (respiratory irritation). Classified for acute oral toxicity Category 4. Must be used at low concentrations in cosmetics with pH-dependent activity more pronounced at lower pH values. The EU classifies Phenoxyacetic Acid as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Phenoxyacetic Acid allowed in the EU?
Phenoxyacetic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenoxyacetic Acid do in cosmetics?
Phenoxyacetic Acid functions as: Fragrance ingredient; pH adjuster; preservative booster in some systems. It is classified as a cosmetic ingredient in our database. CAS number: 122-59-8.
What is the Margin of Safety for Phenoxyacetic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenoxyacetic Acid?
The NOAEL (No Observed Adverse Effect Level) for Phenoxyacetic Acid is 800 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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