What is the NOAEL for C.I. Pigment Yellow 100?
C.I. Pigment Yellow 100 has 21 NOAEL studies in the database. The lowest reported value is 1469.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
C.I. Pigment Yellow 100
Also known as: FD&C yellow No. 5 aluminum lake (C.I. Pigment yellow 100), C.I. 19140:1, C.I. Acid Yellow 23-aluminum lake, Acid Yellow 23-aluminum lake, EINECS 235-428-9 (+15 more)
CAS 12225-21-7
C.I. Pigment Yellow 100 (CAS 12225-21-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Acid Yellow 3 Aluminum Lake →
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
C.I. Pigment Yellow 100
CAS Number
12225-21-7
DTXSID
DTXSID2025921
Molecular Formula
3C16H12N4O9S2.Al
InChI Key
WNVDZDLVUGYYKK-HBGYKRQNSA-K
Monoisotopic Mass
1430.99525
Synonyms
FD&C yellow No. 5 aluminum lake (C.I. Pigment yellow 100)C.I. 19140:1C.I. Acid Yellow 23-aluminum lakeAcid Yellow 23-aluminum lakeEINECS 235-428-9Food Yellow No. 4-aluminum lakeJapan Yellow 4 lakeJapan Yellow 4-aluminum lakeTartrazine aluminum lake11671 YellowAluminum indigo carmineC.I. 19140 Aluminum Lake
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
DyePigment
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1469.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| JQ6BLH9FR7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JQ6BLH9FR7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JQ6BLH9FR7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| JQ6BLH9FR7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1767.8 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =642 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 984 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1064 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1105 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 2190 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2641 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2995 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 8919 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex | 235-428-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E102 (Lake) — ADI: 7.5 mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include C.I. Pigment Yellow 100?
C.I. Pigment Yellow 100 appears on 3 regulatory/inventory lists including SCIL (9/2019), inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is C.I. Pigment Yellow 100 used in cosmetics?
Yes, C.I. Pigment Yellow 100 is also indexed as a cosmetic ingredient under the name Acid Yellow 3 Aluminum Lake. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for C.I. Pigment Yellow 100 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is C.I. Pigment Yellow 100 used outside industrial chemicals?
C.I. Pigment Yellow 100 also appears in cosmetics, food safety databases.