Is Acid Yellow 3 Aluminum Lake safe in cosmetics?
Acid Yellow 3 Aluminum Lake has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Acid Yellow 3 Aluminum Lake
Also known as: FD&C yellow No. 5 aluminum lake (C.I. Pigment yellow 100), C.I. 19140:1, C.I. Acid Yellow 23-aluminum lake, Acid Yellow 23-aluminum lake, EINECS 235-428-9 (+15 more)
INCI: ACID YELLOW 3 ALUMINUM LAKE
Acid Yellow 3 Aluminum Lake (CAS 12225-21-7) is a cosmetic cosmetic ingredient functioning as Colorant (pigment/lake form). NOAEL 589.267 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 12225-21-7 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant (pigment/lake form)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
aluminum tris(4-[[3-carboxy-5-oxo-1-(4-sulfophenyl)-4H-pyrazol-4-yl]diazenyl]benzenesulfonate)
InChIKey
WNVDZDLVUGYYKK-UHFFFAOYSA-K
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
FDA-listed as D&C Yellow No. 10 Aluminum Lake; permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Yellow 3 Aluminum Lake.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Yellow 3 Aluminum Lake. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 984 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1064 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1105 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2190 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2641 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Acid Yellow 3 Aluminum Lake across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LOAEL | =1767.8 mg/kg-day | Mouse | oral | - | ECHA IUCLID |
| NOAEL | =642 mg/kg-day | Mouse | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Acid Yellow 3 Aluminum Lake.
Regulatory Flags
colorant
epa_safer_alternative
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Yellow 3 Aluminum Lake by CAS number or substance name.
Studies
13
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
5000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
FD&C yellow No. 5 aluminum lake (C.I. Pigment yellow 100)
C.I. 19140:1
C.I. Acid Yellow 23-aluminum lake
Acid Yellow 23-aluminum lake
EINECS 235-428-9
Food Yellow No. 4-aluminum lake
Japan Yellow 4 lake
Japan Yellow 4-aluminum lake
Tartrazine aluminum lake
11671 Yellow
Aluminum indigo carmine
C.I. 19140 Aluminum Lake
C.I. Food Yellow 4 Aluminum Lake
C.I. Food Yellow 4:1
Certolake Tartrazine
Certolake Tartrazol Yellow
FD&C Yellow #5 Aluminum Lake
FD&C Yellow 5 Lake
Japan Food Yellow No. 4 aluminum lake
Lakolene B 3014
Chemical Function
Dye
Pigment
Regulatory Lists
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Acid Yellow 3 Aluminum Lake allowed in the EU?
Acid Yellow 3 Aluminum Lake EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Yellow 3 Aluminum Lake do in cosmetics?
Acid Yellow 3 Aluminum Lake functions as: Colorant (pigment/lake form). It is classified as a cosmetic ingredient in our database. CAS number: 12225-21-7.
What is the NOAEL for Acid Yellow 3 Aluminum Lake?
The NOAEL (No Observed Adverse Effect Level) for Acid Yellow 3 Aluminum Lake is 500 mg/kg bw/day based on a Neurotoxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Acid Yellow 3 Aluminum Lake used outside cosmetics?
Acid Yellow 3 Aluminum Lake also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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