Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Yellow 3 Aluminum Lake. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 750 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2641 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 984 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
Expert Verdict
Restricted under Annex III entry 326 with concentration limits; parent dye restrictions apply in hair dye applications but aluminum lake form is permitted in other cosmetic uses.
Regulatory Flags
Frequently Asked Questions
Is Acid Yellow 3 Aluminum Lake safe in cosmetics?
Restricted under Annex III entry 326 with concentration limits; parent dye restrictions apply in hair dye applications but aluminum lake form is permitted in other cosmetic uses. The EU classifies Acid Yellow 3 Aluminum Lake as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Acid Yellow 3 Aluminum Lake allowed in the EU?
Acid Yellow 3 Aluminum Lake EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Yellow 3 Aluminum Lake do in cosmetics?
Acid Yellow 3 Aluminum Lake functions as: Colorant (pigment/lake form). It is classified as a cosmetic ingredient in our database. CAS number: 12225-21-7.
What is the Margin of Safety for Acid Yellow 3 Aluminum Lake?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Acid Yellow 3 Aluminum Lake?
The NOAEL (No Observed Adverse Effect Level) for Acid Yellow 3 Aluminum Lake is 750 mg/kg bw/day based on a Multigeneration Reproductive study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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