What is the NOAEL for Diethyl butanedioate?
Diethyl butanedioate has 10 NOAEL studies in the database. The lowest reported value is ELP55C13DR UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethyl butanedioate
Also known as: Butanedioic acid, diethyl ester, 4-02-00-01914, BRN 0907645, Diethyl ethanedicarboxylate, EINECS 204-612-0 (+3 more)
CAS 123-25-1
Diethyl butanedioate (CAS 123-25-1) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Diethyl butanedioate
CAS Number
123-25-1
DTXSID
DTXSID2038732
Molecular Formula
C8H14O4
InChI Key
DKMROQRQHGEIOW-UHFFFAOYSA-N
Monoisotopic Mass
174.089209
Synonyms
Butanedioic acid, diethyl ester4-02-00-01914BRN 0907645Diethyl ethanedicarboxylateEINECS 204-612-0FEMA No. 2377Diethylester kyseliny jantaroveUNII-ELP55C13DR
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
SolventSoftener and conditionerPlasticizerDeodorizerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; Europe; Personal care - body adhesive | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ELP55C13DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ELP55C13DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ELP55C13DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ELP55C13DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2700 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =8530 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 15000 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diethyl succinate | 204-612-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SUCCINIC ACID DIETHYL ESTER
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Diethyl butanedioate?
Diethyl butanedioate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, detected; Europe; Personal care - body adhesive, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is Diethyl butanedioate used in cosmetics?
Yes, Diethyl butanedioate is also indexed as a cosmetic ingredient under the name Diethyl Succinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethyl butanedioate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethyl butanedioate used outside industrial chemicals?
Diethyl butanedioate also appears in cosmetics, pharmaceutical, cannabis databases.