Is Diethyl Succinate safe in cosmetics?
Diethyl Succinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Diethyl Succinate
Also known as: Butanedioic acid, diethyl ester, 4-02-00-01914, BRN 0907645, Diethyl ethanedicarboxylate, EINECS 204-612-0 (+3 more)
INCI: DIETHYL SUCCINATE
Diethyl Succinate (CAS 123-25-1) is a cosmetic cosmetic ingredient functioning as Fragrance, Plasticizer, Emollient, Solvent. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Fragrance, Plasticizer, Emollient, Solvent
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
diethyl butanedioate
InChIKey
DKMROQRQHGEIOW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel (2010/2012 Final Report) concluded safe in present practices of use and concentration as part of a 56-ingredient dicarboxylic acid group assessment. Holds FEMA GRAS No. 2377 for food flavoring.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethyl Succinate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is mildly irritating to the eyes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethyl Succinate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1079
Source: WHO/JECFA
Regulatory (5)
JECFA Number
617
Source: WHO/JECFA
JECFA Evaluation
DIETHYL BUTANEDIOATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: WHO/JECFA
JECFA Evaluation
ETHYL SUCCINATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: WHO/JECFA
JECFA Evaluation
DIETHYL ETHANEDICARBOXYLATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: WHO/JECFA
JECFA Evaluation
DIETHYL SUCCINATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Plasticizer
Softener and conditioner
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Diethyl Succinate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cir-safe
rifm-assessed
fema-gras
fragrance-ingredient
no-sccs-opinion
no-mos-calculated
synthetic-ester
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethyl Succinate by CAS number or substance name.
Studies
3
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
Butanedioic acid, diethyl ester
4-02-00-01914
BRN 0907645
Diethyl ethanedicarboxylate
EINECS 204-612-0
FEMA No. 2377
Diethylester kyseliny jantarove
UNII-ELP55C13DR
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
detected; Europe; Personal care - body adhesive
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SUCCINIC ACID DIETHYL ESTER
ChEMBL ID
CHEMBL369243
Frequently Asked Questions
Is Diethyl Succinate allowed in the EU?
Diethyl Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Succinate do in cosmetics?
Diethyl Succinate functions as: Fragrance, Plasticizer, Emollient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 123-25-1.
Is Diethyl Succinate used outside cosmetics?
Diethyl Succinate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethyl Succinate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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