Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diethyl Succinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 15000 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Clean safety profile supported by CIR group clearance and RIFM dedicated assessment; metabolizes to succinic acid and ethanol with no genotoxicity or reproductive toxicity identified.
Regulatory Flags
Frequently Asked Questions
Is Diethyl Succinate safe in cosmetics?
Clean safety profile supported by CIR group clearance and RIFM dedicated assessment; metabolizes to succinic acid and ethanol with no genotoxicity or reproductive toxicity identified. The EU classifies Diethyl Succinate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Diethyl Succinate allowed in the EU?
Diethyl Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethyl Succinate do in cosmetics?
Diethyl Succinate functions as: Fragrance, Plasticizer, Emollient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 123-25-1.
What is the Margin of Safety for Diethyl Succinate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethyl Succinate?
The NOAEL (No Observed Adverse Effect Level) for Diethyl Succinate is 15000 mg/kg bw/day based on a Special Toxicology Study study via oral route in mouse. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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