Warning GHS08GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

4-Aminophenol

Also known as: EINECS 204-616-2, p-Aminofenol, UNII-R7P8FRP05V, Activol, Aminophenol (+2 more)

CAS 123-30-8

4-Aminophenol (CAS 123-30-8) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H332; H302; H400; H410. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for P-AMINOPHENOL →

SOURCE NOAEL studies
NOAEL studies
44
SOURCE Chemical inventory jurisdictions
Regulatory lists
17
SOURCE EU CLP Annex VI
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
4-Aminophenol
CAS Number
123-30-8
Molecular Formula
C6H7NO
InChI Key
PLIKAWJENQZMHA-UHFFFAOYSA-N
Monoisotopic Mass
109.052764
Synonyms
EINECS 204-616-2p-AminofenolUNII-R7P8FRP05VActivolAminophenolEnergolParamidophenol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1H341; H332; H302; H400; H410GHS08; GHS07; GHS09Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloring - hair color - professionalDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
detected; Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
-Danish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 44 of 44 studies
ValueUnitEndpointRouteSpeciesSource
3--oralratRegulatory source
10mg/kg bw/day-dermalrabbitRegulatory source
24---humanRegulatory source
1409---humanRegulatory source
=0.016mg/kg bw/dayADI-ConsumersEFSA
=0.05mg/kg bw/dayARfD-ConsumersEFSA
=2.1mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
R7P8FRP05VUNIIFDA UNII substance identifier--openFDA substances
>0.005mg/LLC50Inhalation-NTP ICE acute inhalation
=467mg/kg bw/dayLELoralRatECHA
=667mg/kg bw/dayLELoralRatECHA
30mg/kg bw/dayLOAELoralratCOSMOS DB
133mg/kg bw/dayLOAELoralratCOSMOS DB
=133mg/kg bw/dayLOAELoralRatECHA
=30mg/kg bw/dayLOELoralRatECHA
=0.067mg/kg bw/dNOAELoralratSCCS Opinion
=3-NOAELoralratSCCS Opinion
=3.2mg/kg bw/dayNOAELoralRatEFSA
=3.2mg/kg bw/dayNOAEL-RatEFSA
=5.2mg/kg bw/dayNOAELoralRatEFSA
=5.2mg/kg bw/dayNOAELoral: unspecifiedRatEFSA
=6.9µg/cmNOAELdermalhumanSCCS Opinion
10mg/kg bw/dayNOAELoralratCOSMOS DB
=10mg/kg bw/dayNOAELoralRatECHA
=10mg/kgNOAELoralratSCCS Opinion
=10mg/kg bw/dayNOAELdermalrabbitSCCS Opinion
=10mg/kg bw/dNOAELoralratSCCS Opinion
=20mg/kg bw/dayNOAELoralRatECHA
=24-NOAEL-humanSCCS Opinion
=25mg/kgNOAELoralratSCCS Opinion
47mg/kg bw/dayNOAELoralratCOSMOS DB
=50mg/kg bw/dayNOAELoralRatToxValDB PPRTV (CPHEA)
=100mg/kg bw/dayNOAELoralRatECHA
=333mg/kg bw/dayNOAELoralRatECHA
=1409-NOAEL-humanSCCS Opinion
=30mg/kg bw/dayNOECoralRatECHA
=0.02mg/kg bw/dayRfD (provisional)oralHumanToxValDB PPRTV (CPHEA)
=0.2mg/kg bw/dayRfD (provisional)oralHumanToxValDB PPRTV (CPHEA)
=0.067mg/kg bw/ddermal absorptionoralratRegulatory source
=6.9µg/cmdermal absorptiondermalhumanRegulatory source
=10mg/kg bw/ddermal absorptionoralratRegulatory source
25mg/kggenotoxicityoralratRegulatory source
10mg/kgrepeated dose toxicityoralratRegulatory source
10mg/kg bw/dayrepeated dose toxicitydermalrabbitRegulatory source

Showing 44 of 44 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
Registered4-aminophenol204-616-2ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 3 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1453/1113-14 December 2011safe1.0%strong sensitiser; MoS adequate
SCCP/0854/0415 March 2005safe1.0%strong sensitiser; MoS adequate
SCCS/1409/112011-12-14Based on the data provided, the SCCS is of the opinion that the use of p-aminophenol with a maximum on-head concentration of 0.9% in oxidative hair dye formulations does not pose a risk to the health of the consumer, apart from its sensitising potential.0.9%Sensitising potential (safe “apart from its sensitising potential”).

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
III/272 - (EC) No 1197/2013
Category
Hair Dyes
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed 4-AMINOPHENOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 4-Aminophenol?

4-Aminophenol (CAS 123-30-8) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H341; H332; H302; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4-Aminophenol?

4-Aminophenol has 44 NOAEL studies in the database. The lowest reported value is 0.005 mg/L via Inhalation. Source: NTP ICE acute inhalation.

What regulatory lists include 4-Aminophenol?

4-Aminophenol appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring - hair color - professional, and 2 more. Source: EPA CPDat.

Is 4-Aminophenol used in cosmetics?

Yes, 4-Aminophenol is also indexed as a cosmetic ingredient under the name P-AMINOPHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Aminophenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Aminophenol have different safety status in cosmetics vs industrial chemicals?

4-Aminophenol is classified GHS CMR hazard (H341, H332, H302, H400, H410) in the chemicals database but is restricted in EU cosmetics at max III/272 - (EC) No 1197/2013.

Is 4-Aminophenol used outside industrial chemicals?

4-Aminophenol also appears in cosmetics, pharmaceutical, cannabis databases.