Warning GHS08GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

4-Aminophenol

Also known as: EINECS 204-616-2, p-Aminofenol, UNII-R7P8FRP05V, Activol, Aminophenol (+2 more)

CAS 123-30-8

4-Aminophenol (CAS 123-30-8) is a chemical substance with GHS signal word Warning; key hazard signal: H341; H332; H302; H400; H410. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for P-AMINOPHENOL →

Cross-Vertical Regulatory Divergence

4-Aminophenol is classified GHS CMR hazard (H341, H332, H302, H400, H410) in the chemicals database but is restricted in EU cosmetics at max III/272 - (EC) No 1197/2013.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

4-Aminophenol

CAS Number

123-30-8

DTXSID

DTXSID3024499

Molecular Formula

C6H7NO

InChI Key

PLIKAWJENQZMHA-UHFFFAOYSA-N

Monoisotopic Mass

109.052764

Synonyms

EINECS 204-616-2p-AminofenolUNII-R7P8FRP05VActivolAminophenolEnergolParamidophenol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Muta. 2; Acute Tox. 4 ; Acute Tox. 4 ; Aquatic Acute 1; Aquatic Chronic 1	H341; H332; H302; H400; H410	GHS08; GHS07; GHS09	Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring - hair color - professional	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
-	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 79 studies

Value	Unit	Endpoint	Route	Species	Source
3	-	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10	mg/kg bw/day	-	dermal	rabbit	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10	mg/kg bw/day	-	dermal	rabbit	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
24	-	-	-	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1409	-	-	-	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1409	-	-	-	human	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.016	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.016	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.05	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.05	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=2.1	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
R7P8FRP05V	UNII	FDA UNII substance identifier	-	-	openFDA substances
R7P8FRP05V	UNII	FDA UNII substance identifier	-	-	openFDA substances
R7P8FRP05V	UNII	FDA UNII substance identifier	-	-	openFDA substances
R7P8FRP05V	UNII	FDA UNII substance identifier	-	-	openFDA substances
>0.005	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=467	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=667	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
30	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
133	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=133	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=30	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.067	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.067	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=3	-	NOAEL	oral	rat	SCCS_vision_codex
=3	-	NOAEL	oral	rat	SCCS_vision_codex
=3	-	NOAEL	oral	rat	SCCS_vision_codex
=3	-	NOAEL	oral	rat	SCCS_vision_codex
=3.2	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=3.2	mg/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=5.2	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=5.2	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=6.9	µg/cm	NOAEL	dermal	human	SCCS_vision_codex
=6.9	µg/cm	NOAEL	dermal	human	SCCS_vision_codex
=6.9	µg/cm	NOAEL	dermal	human	SCCS_vision_codex
=6.9	µg/cm	NOAEL	dermal	human	SCCS_vision_codex
10	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=10	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	dermal	rabbit	SCCS_vision_codex
=10	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	dermal	rabbit	SCCS_vision_codex
=10	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	dermal	rabbit	SCCS_vision_codex
=10	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex

Showing 50 of 79 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	4-aminophenol	204-616-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1453/11	13-14 December 2011	safe	1.0%	strong sensitiser; MoS adequate
SCCP/0854/04	15 March 2005	safe	1.0%	strong sensitiser; MoS adequate

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

III/272 - (EC) No 1197/2013

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 4-AMINOPHENOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 4-Aminophenol?

4-Aminophenol (CAS 123-30-8) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H341; H332; H302; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 4-Aminophenol?

4-Aminophenol has 79 NOAEL studies in the database. The lowest reported value is 0.005 mg/L via Inhalation. Source: NTP_ICE_acute_inhalation.

What regulatory lists include 4-Aminophenol?

4-Aminophenol appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care - hair coloring, detected; Europe; Personal care - hair coloring - hair color - professional, and 2 more. Source: EPA CPDat.

Is 4-Aminophenol used in cosmetics?

Yes, 4-Aminophenol is also indexed as a cosmetic ingredient under the name P-AMINOPHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Aminophenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Aminophenol have different safety status in cosmetics vs industrial chemicals?

4-Aminophenol is classified GHS CMR hazard (H341, H332, H302, H400, H410) in the chemicals database but is restricted in EU cosmetics at max III/272 - (EC) No 1197/2013.

Is 4-Aminophenol used outside industrial chemicals?

4-Aminophenol also appears in cosmetics, pharmaceutical, cannabis databases.