Also known as: EINECS 204-616-2, p-Aminofenol, UNII-R7P8FRP05V, Activol, Aminophenol (+2 more)
P-AMINOPHENOL (CAS 123-30-8) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max III/272 - (EC) No 1197/2013; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
P-AMINOPHENOL is classified GHS Danger (H302, H332, H317, H341, H373, H400, H410, H316) in the chemicals database but is restricted in EU cosmetics at max III/272 - (EC) No 1197/2013.
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
10 study endpoints found for P-AMINOPHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS DB |
| NOAEL | =0.067 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.067 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.067 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.067 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =10 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =10 mg/kg bw/day | dermal | rabbit | NOAEL study | SCCS Opinion |
| NOAEL | =10 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =10 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =10 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for P-AMINOPHENOL across SCCS product categories, with measured dermal absorption where available.
Contact sensitization data for P-AMINOPHENOL based on clinical patch test studies and IFRA standards.
Source: IVDK; NACDG; ESSCA
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 1 | Oxidative hair dye products |
| IN | restricted | 1.3 | oxidative hair dye products |
| BR | permitted_hair_dye | - | Oxidative hair dye |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Source: EPA Dryad Skin Absorption 2024
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 13.0% | - | - | SCCP/0000 |
| measured | 6.0% | - | - | SCCP/0000 |
| measured | 2.9% | - | - | SCCP/0000 |
| measured | 2.95% | - | - | SCCP/0000 |
| measured | 13.0% | - | - | SCCS/0078 |
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Preliminary editorial summary for P-AMINOPHENOL — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to P-AMINOPHENOL by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 13.0% | - | - |
| 6.0% | - | - |
| 2.9% | - | - |
| 2.95% | - | - |
| 13.0% | - | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
P-AMINOPHENOL has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
P-AMINOPHENOL EU regulatory status: restricted. Maximum allowed concentration: III/272 - (EC) No 1197/2013. This is based on EU Regulation 1223/2009 and its amendments.
P-AMINOPHENOL functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 123-30-8.
The NOAEL (No Observed Adverse Effect Level) for P-AMINOPHENOL is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS DB.
P-AMINOPHENOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
P-AMINOPHENOL is classified GHS Danger (H302, H332, H317, H341, H373, H400, H410, H316) in the chemicals database but is restricted in EU cosmetics at max III/272 - (EC) No 1197/2013.
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