What is the NOAEL for Myrcene?
Myrcene has 34 NOAEL studies in the database. The lowest reported value is 0.5 mg/kg bw/day. Source: WHO/JECFA.
NOAEL Data
IARC Group 2B
Prop 65
REACH Registered
Cosmetic Ingredient
Myrcene
Also known as: beta-Myrcene, 1,6-Octadiene, 7-methyl-3-methylene-, 4-01-00-01108, BRN 1719990, EINECS 204-622-5 (+13 more)
CAS 123-35-3
Myrcene (CAS 123-35-3) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: California Proposition 65, REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
Myrcene is classified GHS Danger (H226, H304, H315, H319, H400, H412, H351, H361) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
34
SOURCE
Chemical inventory jurisdictions
Regulatory lists
15
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Myrcene
CAS Number
123-35-3
Molecular Formula
C10H16
InChI Key
UAHWPYUMFXYFJY-UHFFFAOYSA-N
Monoisotopic Mass
136.125201
Synonyms
beta-Myrcene1,6-Octadiene, 7-methyl-3-methylene-4-01-00-01108BRN 1719990EINECS 204-622-5FEMA No. 2762UNII-3M39CZS25B3-Methylene-7-methyl-1, 6-octadiene7-Methyl-3-methylene-1,6-octadiene (beta -myrcene)7-Methyl-3-methylene-1,6-octadiene (myrcene)7-Methyl-3-methylene-octa-1,6-diene7-Methyl-3-methyleneoctadiene-(1,6)
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2017 | 119 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
32 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 34 of 34 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 3M39CZS25B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP ICE cancer |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =250 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =250 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =250 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB HPVIS |
| =500 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB HPVIS |
| =500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =500 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =1000 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB HPVIS |
| =1000 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB ToxRefDB |
| =1000 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =1200 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB HPVIS |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =44 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =44 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =250 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB HPVIS |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HPVIS |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HPVIS |
| =500 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB ToxRefDB |
| =500 | mg/kg bw/day | NOAEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| 1200 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 250 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Mouse | NTP ICE cancer |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| =0.2 | mg/kg bw/day | TDI | oral | - | WHO/JECFA |
| 1000 | mg/kg | Top dose | Gavage | Mouse | NTP ICE cancer |
Showing 34 of 34 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 7-methyl-3-methyleneocta-1,6-diene | 204-622-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
MYRCENE
ChEMBL Phase
1
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Myrcene?
Myrcene appears on 12 regulatory/inventory lists including Cleaning products and household care - air freshener; Europe, air; Cleaning products and household care - air freshener; detected; emissions; Europe, detected; Europe; Personal care - liniment, and 9 more. Source: EPA CPDat.
Is Myrcene a carcinogen according to IARC?
Myrcene is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2017). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Myrcene on the California Proposition 65 list?
Yes, Myrcene is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Myrcene used in cosmetics?
Yes, Myrcene is also indexed as a cosmetic ingredient under the name MYRCENE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Myrcene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Myrcene have different safety status in cosmetics vs industrial chemicals?
Myrcene is classified GHS Danger (H226, H304, H315, H319, H400, H412, H351, H361) in the chemicals database but is allowed in EU cosmetics.
Is Myrcene used outside industrial chemicals?
Myrcene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.