Good Cosmetic Ingredient NOAEL Data

MYRCENE

CAS Number

123-35-3

Function

Perfuming

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status prohibited

US Notes | Allowed — FEMA GRAS No. 2762 for flavor use; not prohibited in cosmetics scentspiracy | | **Safety Concerns** | Oxidation products may cause skin sensitization — stabilization with antioxidants is recommended; classified as flammable under REACH; auto-polymerizes under air/light exposure scents...

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for MYRCENE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	500 mg/kg bw/day	oral	rat	Reproductive	COSMOS_DB
NOAEL	1200 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
NOAEL	500 mg/kg bw/day	oral	rat	Reproductive	COSMOS_DB
NOAEL	500 mg/kg bw/day	oral	rat	Reproductive-developmental	COSMOS_DB
NOAEL	1500 mg/kg bw/day	oral	mouse	Special Toxicology Study	COSMOS_DB
LOAEL	250 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	250 mg/kg bw/day	oral	mouse	oral	REACH
NOAEL	53 mg/kg bw/day	oral	rat	oral	REACH

Expert Verdict

MYRCENE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment prop65 ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is MYRCENE safe in cosmetics?

MYRCENE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies MYRCENE as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is MYRCENE allowed in the EU?

MYRCENE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does MYRCENE do in cosmetics?

MYRCENE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 123-35-3.

What is the NOAEL for MYRCENE?

The NOAEL (No Observed Adverse Effect Level) for MYRCENE is 500 mg/kg bw/day based on a Reproductive study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check MYRCENE compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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