Warning GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Butyl acetate

Also known as: 4-02-00-00143, BRN 1741921, EINECS 204-658-1, Acetate de butyle, Butylacetaten (+11 more)

CAS 123-86-4

Butyl acetate (CAS 123-86-4) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H336. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Butyl Acetate →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

Butyl acetate

CAS Number

123-86-4

Molecular Formula

C6H12O2

InChI Key

DKPFZGUDAPQIHT-UHFFFAOYSA-N

Monoisotopic Mass

116.08373

Synonyms

4-02-00-00143BRN 1741921EINECS 204-658-1Acetate de butyleButylacetatenButylester kyseliny octoveOctan n-butyluUNII-464P5N19051-Butanol, acetate1-ButylacetateButylacetatButylazetat

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; STOT SE 3	H226; H336	GHS02; GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 9 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	150 ppm (710 mg/m³)	150	710	N
NIOSH	TWA	150 ppm (710 mg/m³)	150	710	N
NIOSH	STEL	200 ppm (950 mg/m³)	200	950	N
CAL/OSHA	TWA	150 ppm (710 mg/m³)	150	710	-
CAL/OSHA	STEL	200 ppm (950 mg/m³)	200	950	-
NIOSH	IDLH	1700 ppm	1700	-	-
AIHA	ERPG-1	5 ppm	5	-	-
AIHA	ERPG-2	200 ppm	200	-	-
AIHA	ERPG-3	3000 ppm	3000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventDeodorizerNo specific technical functionFragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
air; detected; emissions; Personal care	Elsevier	CPCat
Cons electronics mech appliances and machinery; detected; Europe	Danish EPA	Danish EPA
Cons electronics mech appliances and machinery; detected; Europe	Danish EPA	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
Arts and crafts/Office supplies; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies; Europe	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies

Value	Unit	Endpoint	Route	Species	Source
<=6	mg/kg bw	ADI (provisional)	-	Consumers	EFSA
=300	mg/m3	DNEL local	inhalation	Human	ToxValDB GESTIS DNEL
=48	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
7.5	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP ICE eye irritation
3	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
464P5N1905	UNII	FDA UNII substance identifier	-	-	openFDA substances
0	%	Incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
2700	ug/cm2	Induction dose per skin area	Dermal	Human	NTP ICE skin sensitization
0.15	%/sec	Intensity	Ocular	-	NTP ICE eye irritation
1.852	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
>3200	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
>6400	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
>8800	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.070e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.074e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.077e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.270e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.276e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.310e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=1.413e+4	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
=2.134e+4	mg/m3	LEL	inhalation	Rat	ECHA
=3.962e+4	mg/m3	LEL	inhalation	Rat	ECHA
=6.176e+4	mg/m3	LEL	inhalation	Human	ToxValDB DOE Protective Action Criteria
=3563	mg/m3	LOAEC	inhalation	Rat	ECHA
=7126	mg/m3	LOAEC	inhalation	Rat	ECHA
=3.801e+4	mg/m3	LOAEC	inhalation	Mouse	ECHA
2000	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
=700	mg/m3	LOAEL (HEC)	inhalation	Human	ToxValDB TX TCEQ
10	s	Lag time	Ocular	-	NTP ICE eye irritation
=2375	mg/m3	NOAEC	inhalation	Rat	ECHA
=7126	mg/m3	NOAEC	inhalation	Rabbit	ECHA
=9502	mg/m3	NOAEC	inhalation	Rat	ECHA
0.5	mg/kg bw/day	NOAEL	oral	rabbit	COSMOS DB
600	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
800	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
~1500	mg/kg bw/day	NOAEL	-	-	WHO/JECFA
2000	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=2375	mg/m3	NOAEL	inhalation	Rat	ToxValDB TX TCEQ
3000	mg/kg bw/day	NOAEL	oral	mouse	COSMOS DB
26.3	%	Plateau level	Ocular	-	NTP ICE eye irritation
3	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization
5	unitless	Relative reliability score	Dermal	Human	NTP ICE skin sensitization

Showing 42 of 42 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	N-butyl acetate	204-658-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed ACETIC ACID BUTYL ESTER

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Butyl acetate?

Butyl acetate (CAS 123-86-4) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3 with signal word Warning. Hazard statements: H226; H336. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Butyl acetate?

Butyl acetate has 42 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.

What regulatory lists include Butyl acetate?

Butyl acetate appears on 27 regulatory/inventory lists including air; detected; emissions; Personal care, Cons electronics mech appliances and machinery; detected; Europe, inert_ingredient; non_food_use; Pesticides, and 24 more. Source: EPA CPDat.

What are the occupational exposure limits for Butyl acetate?

Occupational exposure limits for Butyl acetate are set by OSHA, NIOSH, CAL/OSHA. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Butyl acetate used in cosmetics?

Yes, Butyl acetate is also indexed as a cosmetic ingredient under the name Butyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Butyl acetate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Butyl acetate used outside industrial chemicals?

Butyl acetate also appears in cosmetics, pharmaceutical, cannabis databases.