Good Cosmetic Ingredient NOAEL Data GHS Classified

Butyl Acetate

INCI: BUTYL ACETATE

CAS Number
123-86-4
Function
Solvent primarily in nail lacquers and coatings
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Adequate — Inhalation OEL established (TWA 150 ppm / 713 mg/m³)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Butyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 0.5 mg/kg bw/day oral rabbit Chronic COSMOS_DB
NOAEL 0.5 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 800 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 3000 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 2000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 2000 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 600 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 2000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 0.5 mg/kg bw/day oral rabbit Chronic COSMOS_DB
dose_tested 0.5 mg/kg bw/day oral rat Chronic COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.

Expert Verdict

Volatile and flammable solvent requiring ventilation during application. Inhalation exposure is the primary route of concern in professional nail settings; not a concern in rinse-off or leave-on skin products.

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Concern Level: Low

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Butyl Acetate safe in cosmetics?

Volatile and flammable solvent requiring ventilation during application. Inhalation exposure is the primary route of concern in professional nail settings; not a concern in rinse-off or leave-on skin products. The EU classifies Butyl Acetate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Butyl Acetate allowed in the EU?

Butyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Butyl Acetate do in cosmetics?

Butyl Acetate functions as: Solvent primarily in nail lacquers and coatings. It is classified as a cosmetic ingredient in our database. CAS number: 123-86-4.

What is the Margin of Safety for Butyl Acetate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Butyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Butyl Acetate is 0.5 mg/kg bw/day based on a Chronic study via oral route in rabbit. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Butyl Acetate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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