What is the NOAEL for Nonanedioic acid?
Nonanedioic acid has 7 NOAEL studies in the database. The lowest reported value is 17.632 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Nonanedioic acid
Also known as: Azelaic acid, Emery 1110, ZK 62498, Emery 1144, Empol 1144 (+15 more)
CAS 123-99-9
Nonanedioic acid (CAS 123-99-9) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Nonanedioic acid
CAS Number
123-99-9
DTXSID
DTXSID8021640
Molecular Formula
C9H16O4
InChI Key
BDJRBEYXGGNYIS-UHFFFAOYSA-N
Monoisotopic Mass
188.104859
Synonyms
Azelaic acidEmery 1110ZK 62498Emery 1144Empol 11444-02-00-02055Azelaic acid, technical gradeBRN 1101094EINECS 204-669-1Heptanedicarboxylic acidAcidum azelaicumUNII-F2VW3D43YT
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
DeodorizerpH regulating agentFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =17.632 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| F2VW3D43YT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F2VW3D43YT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F2VW3D43YT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| F2VW3D43YT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Azelaic acid | 204-669-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
AZELAIC ACID
ChEMBL Phase
4
Adverse Events
3124
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Nonanedioic acid?
Nonanedioic acid appears on 4 regulatory/inventory lists including pharmaceutical, Indirect additives food contact (10/2018), Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Is Nonanedioic acid used in cosmetics?
Yes, Nonanedioic acid is also indexed as a cosmetic ingredient under the name Azelaic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Nonanedioic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Nonanedioic acid used outside industrial chemicals?
Nonanedioic acid also appears in cosmetics, pharmaceutical, cannabis databases.