What is the NOAEL for Spermidine?
Spermidine has 4 NOAEL studies in the database. The lowest reported value is U87FK77H25 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Spermidine
Also known as: 1,4-Butanediamine, N-(3-aminopropyl)-, 1,4-Butanediamine, N1-(3-aminopropyl)-, Spermidin, N-(3-Aminopropyl)-4-aminobutylamine, 4-04-00-01300 (+10 more)
CAS 124-20-9
Spermidine (CAS 124-20-9) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Spermidine is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Spermidine
CAS Number
124-20-9
DTXSID
DTXSID4036645
Molecular Formula
C7H19N3
InChI Key
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Monoisotopic Mass
145.157898
Synonyms
1,4-Butanediamine, N-(3-aminopropyl)-1,4-Butanediamine, N1-(3-aminopropyl)-SpermidinN-(3-Aminopropyl)-4-aminobutylamine4-04-00-01300BRN 16985911,4-Diaminobutane, N-(3-aminopropyl)-EINECS 204-689-0UNII-U87FK77H25(4-aminobutyl)(3-aminopropyl)amineAminopropylbutandiamineN-(3-Aminopropyl)-1,4-diamino-butane
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
AntioxidantSoftener and conditionerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| U87FK77H25 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U87FK77H25 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U87FK77H25 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U87FK77H25 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SPERMIDINE
ChEMBL Phase
3
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Spermidine?
Spermidine appears on 2 regulatory/inventory lists including IFRA Transparency, Canada; pharmaceutical. Source: EPA CPDat.
Is Spermidine used in cosmetics?
Yes, Spermidine is also indexed as a cosmetic ingredient under the name Spermidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Spermidine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Spermidine have different safety status in cosmetics vs industrial chemicals?
Spermidine is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Is Spermidine used outside industrial chemicals?
Spermidine also appears in cosmetics, pharmaceutical databases.