Regulatory Status
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Safety Data
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Expert Verdict
Endogenous polyamine that induces autophagy, the cellular self-cleaning mechanism degrading damaged organelles. Endogenous spermidine levels correlate inversely with biological age. Declining autophagy with age is partly attributable to falling polyamine levels. Topical application is an active research area with emerging clinical data in skin.
Regulatory Flags
Frequently Asked Questions
Is Spermidine safe in cosmetics?
Endogenous polyamine that induces autophagy, the cellular self-cleaning mechanism degrading damaged organelles. Endogenous spermidine levels correlate inversely with biological age. Declining autophagy with age is partly attributable to falling polyamine levels. Topical application is an active research area with emerging clinical data in skin. The EU classifies Spermidine as "permitted". Safety rating: GOOD.
Is Spermidine allowed in the EU?
Spermidine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Spermidine do in cosmetics?
Spermidine functions as: skin-conditioning, anti-aging, autophagy-inducer. It is classified as a Active Ingredient in our database. CAS number: 124-20-9.
What is the Margin of Safety for Spermidine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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