What is the NOAEL for N,N-Dimethyl-1-octadecanamine?
N,N-Dimethyl-1-octadecanamine has 11 NOAEL studies in the database. The lowest reported value is 1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N-Dimethyl-1-octadecanamine
Also known as: 1-Octadecanamine, N,N-dimethyl-, 3-04-00-00433, Armeen DM 18D, BRN 1763346, N,N-Dimethyloctadecanamine (+15 more)
CAS 124-28-7
N,N-Dimethyl-1-octadecanamine (CAS 124-28-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N,N-Dimethyl-1-octadecanamine is classified GHS Danger (H226, H302, H314, H318, H400, H410, H319, H336) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
N,N-Dimethyl-1-octadecanamine
CAS Number
124-28-7
DTXSID
DTXSID4027026
Molecular Formula
C20H43N
InChI Key
NAPSCFZYZVSQHF-UHFFFAOYSA-N
Monoisotopic Mass
297.33955
Synonyms
1-Octadecanamine, N,N-dimethyl-3-04-00-00433Armeen DM 18DBRN 1763346N,N-DimethyloctadecanamineDimethyloctadecylamineDimethyl-N-octadecylamineN,N-DimethyloctadecylamineN,N-Dimethyl-n-octadecylamineDimethylstearamineN,N-DimethylstearylamineEINECS 204-694-8
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
Anti-static agentEmulsifierSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 066975NG22 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 066975NG22 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 066975NG22 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 066975NG22 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2116 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2118 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =50 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =50 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =50 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimantine | 204-694-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DYMANTHINE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Frequently Asked Questions
What regulatory lists include N,N-Dimethyl-1-octadecanamine?
N,N-Dimethyl-1-octadecanamine appears on 2 regulatory/inventory lists including pharmaceutical, inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is N,N-Dimethyl-1-octadecanamine used in cosmetics?
Yes, N,N-Dimethyl-1-octadecanamine is also indexed as a cosmetic ingredient under the name Dimethyl Stearamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Dimethyl-1-octadecanamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N-Dimethyl-1-octadecanamine have different safety status in cosmetics vs industrial chemicals?
N,N-Dimethyl-1-octadecanamine is classified GHS Danger (H226, H302, H314, H318, H400, H410, H319, H336) in the chemicals database but is allowed in EU cosmetics.
Is N,N-Dimethyl-1-octadecanamine used outside industrial chemicals?
N,N-Dimethyl-1-octadecanamine also appears in cosmetics, pharmaceutical databases.