Is Dimethyl Stearamine safe in cosmetics?
Dimethyl Stearamine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Dimethyl Stearamine
Also known as: 1-Octadecanamine, N,N-dimethyl-, 3-04-00-00433, Armeen DM 18D, BRN 1763346, N,N-Dimethyloctadecanamine (+15 more)
INCI: DIMETHYL STEARAMINE
Dimethyl Stearamine (CAS 124-28-7) is a cosmetic cosmetic ingredient functioning as Antistatic agent. Reported NOAEL =50 mg/kg bw in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 124-28-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dimethyl Stearamine is classified GHS Danger (H226, H302, H314, H318, H400, H410, H319, H336) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
N,N-dimethyloctadecan-1-amine
InChIKey
NAPSCFZYZVSQHF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR reviewed; safe in non-coloring hair care products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethyl Stearamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Dimethyl Stearamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =50 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Emulsifier
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Dimethyl Stearamine.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dimethyl Stearamine by CAS number or substance name.
Studies
4
Lowest NOAEL
50 mg/kg bw
Highest NOAEL
50 mg/kg bw
CIR_vision_codex
Known Synonyms
1-Octadecanamine, N,N-dimethyl-
3-04-00-00433
Armeen DM 18D
BRN 1763346
N,N-Dimethyloctadecanamine
Dimethyloctadecylamine
Dimethyl-N-octadecylamine
N,N-Dimethyloctadecylamine
N,N-Dimethyl-n-octadecylamine
Dimethylstearamine
N,N-Dimethylstearylamine
EINECS 204-694-8
Kemamine 9902D
Octadecylamine, N,N-dimethyl-
Octadecyldimethylamine
Stearyldimethylamine
Adogen 342D
Farmin DM 80
N-Stearyl-N,N-dimethylamine
N-Octadecyl-N,N-dimethylamine
Chemical Function
Anti-static agent
Emulsifier
Softener and conditioner
Regulatory Lists
pharmaceutical
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DYMANTHINE
ChEMBL ID
CHEMBL2110847
Max Phase
2
Frequently Asked Questions
Is Dimethyl Stearamine allowed in the EU?
Dimethyl Stearamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Stearamine do in cosmetics?
Dimethyl Stearamine functions as: Antistatic agent. It is classified as a cosmetic ingredient in our database. CAS number: 124-28-7.
What is the NOAEL for Dimethyl Stearamine?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Stearamine is =50 mg/kg bw based on a developmental toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.
Is Dimethyl Stearamine used outside cosmetics?
Dimethyl Stearamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dimethyl Stearamine have different safety status in cosmetics vs industrial chemicals?
Dimethyl Stearamine is classified GHS Danger (H226, H302, H314, H318, H400, H410, H319, H336) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dimethyl Stearamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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