What is the NOAEL for Carbamide peroxide?
Carbamide peroxide has 5 NOAEL studies in the database. The lowest reported value is 20.1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Carbamide peroxide
Also known as: Urea, compd. with hydrogen peroxide (H2O2) (1:1), EINECS 204-701-4, Hydrogen peroxide, compd. with urea (1:1), Perhydrol-Urea, Carbamide Peroxide Otic Solution (+8 more)
CAS 124-43-6
Carbamide peroxide (CAS 124-43-6) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Carbamide peroxide is classified GHS Danger (H272, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Carbamide peroxide
CAS Number
124-43-6
DTXSID
DTXSID9024726
Molecular Formula
CH4N2O.H2O2
InChI Key
AQLJVWUFPCUVLO-UHFFFAOYSA-N
Monoisotopic Mass
94.037842
Synonyms
Urea, compd. with hydrogen peroxide (H2O2) (1:1)EINECS 204-701-4Hydrogen peroxide, compd. with urea (1:1)Perhydrol-UreaCarbamide Peroxide Otic SolutionUNII-31PZ2VAU81Auro Ear Wax RemoverEar Wax TreatmentThera-earHydrogen peroxide carbamideHydrogen peroxide ureaUrea compound with hydrogen peroxide (1:1)
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Oxidizing agentCatalyst
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =20.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 31PZ2VAU81 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 31PZ2VAU81 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 31PZ2VAU81 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 31PZ2VAU81 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hydrogen peroxide-urea | 204-701-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184026
ChEMBL Phase
Not listed
Adverse Events
111
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Carbamide peroxide?
Carbamide peroxide appears on 3 regulatory/inventory lists including Canada; pharmaceutical, Europe; Personal care - oral and dental care - teeth whitener, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Carbamide peroxide used in cosmetics?
Yes, Carbamide peroxide is also indexed as a cosmetic ingredient under the name Carbamide Peroxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Carbamide peroxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Carbamide peroxide have different safety status in cosmetics vs industrial chemicals?
Carbamide peroxide is classified GHS Danger (H272, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Is Carbamide peroxide used outside industrial chemicals?
Carbamide peroxide also appears in cosmetics, pharmaceutical databases.