Is Carbamide Peroxide safe in cosmetics?
Carbamide Peroxide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Carbamide Peroxide
Also known as: Urea, compd. with hydrogen peroxide (H2O2) (1:1), EINECS 204-701-4, Hydrogen peroxide, compd. with urea (1:1), Perhydrol-Urea, Carbamide Peroxide Otic Solution (+8 more)
INCI: CARBAMIDE PEROXIDE
Carbamide Peroxide (CAS 124-43-6) is a cosmetic cosmetic ingredient functioning as Bleaching/oxidizing agent and oral care agent. NOAEL 216 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 124-43-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Carbamide Peroxide is classified GHS Danger (H272, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Bleaching/oxidizing agent and oral care agent
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel Safety Assessment of Hydrogen Peroxide as Used in Cosmetics - Draft Report, Cosmetic Ingredient Review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Carbamide Peroxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Carbamide Peroxide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
oral_care
{"cas_number": "124-43-6", "ingredient_class": "whitening_agent", "function_primary": "Chemical whitening agent", "function_secondary": "Antimicrobial", "anti_caries_mechanism": "Minimal", "fluoride_content_ppm_if_applicable": "0", "anti_plaque_mechanism": "Mild (releases H2O2)", "biofilm_disruption": "Moderate", "anti_gingivitis_mechanism": "Mild antimicrobial", "anti_inflammatory_oral": "Mild", …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Oxidizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Carbamide Peroxide.
Known Synonyms
Urea, compd. with hydrogen peroxide (H2O2) (1:1)
EINECS 204-701-4
Hydrogen peroxide, compd. with urea (1:1)
Perhydrol-Urea
Carbamide Peroxide Otic Solution
UNII-31PZ2VAU81
Auro Ear Wax Remover
Ear Wax Treatment
Thera-ear
Hydrogen peroxide carbamide
Hydrogen peroxide urea
Urea compound with hydrogen peroxide (1:1)
Urea hydroperoxide
Chemical Function
Oxidizing agent
Catalyst
Regulatory Lists
Canada; pharmaceutical
Europe; Personal care - oral and dental care - teeth whitener
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184026
Adverse Event Associations
111
Frequently Asked Questions
Is Carbamide Peroxide allowed in the EU?
Carbamide Peroxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carbamide Peroxide do in cosmetics?
Carbamide Peroxide functions as: Bleaching/oxidizing agent and oral care agent. It is classified as a cosmetic ingredient in our database. CAS number: 124-43-6.
Is Carbamide Peroxide used outside cosmetics?
Carbamide Peroxide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Carbamide Peroxide have different safety status in cosmetics vs industrial chemicals?
Carbamide Peroxide is classified GHS Danger (H272, H314, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Carbamide Peroxide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Arginine
Excellent
Same category
Amino acid / pH Adjuster
D-Panthenol
Excellent
Same category
Hair and skin conditioning, humectant...
Dicaprylyl Ether
Excellent
Same category
Emollient
Emulsifying Wax
Excellent
Same category
O/W emulsifier; stabilizes oil-in-wat...
Ethyl Butyrate
Excellent
Same category
Perfuming, Masking
Fructose
Excellent
Same category
Humectant, Skin Conditioning, Flavori...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
1,6-Hexanediamine
Poor
Chemical family
Industrial chemical (nylon monomer); ...
Adipic Acid
Excellent
Chemical family
Buffering
Aminomethyl Pro
Good
Chemical family
Insufficient Data
Is Carbamide Peroxide in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Carbamide Peroxide in your formulation.