Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Carbamide Peroxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 ppm | oral | mouse | oral | REACH |
| NOAEL | 216 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 45000 ppm | oral | mouse | oral | REACH |
| NOAEL | 338.4 mg/kg bw/day | dermal | - | dermal | REACH |
| NOAEL | 45000 ppm | oral | rat | oral | REACH |
| NOAEL | 100 ppm | oral | - | oral | REACH |
| NOAEL | 45000 ppm | oral | - | oral | REACH |
| NOAEL | 45000 ppm | oral | - | oral | REACH |
Expert Verdict
Carbamide Peroxide is permitted in EU and US cosmetics, but insufficient safety data exists; further assessment is recommended, particularly for absorption and sensitization potential.
Frequently Asked Questions
Is Carbamide Peroxide safe in cosmetics?
Carbamide Peroxide is permitted in EU and US cosmetics, but insufficient safety data exists; further assessment is recommended, particularly for absorption and sensitization potential. The EU classifies Carbamide Peroxide as "permitted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.
Is Carbamide Peroxide allowed in the EU?
Carbamide Peroxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Carbamide Peroxide do in cosmetics?
Carbamide Peroxide functions as: Bleaching/oxidizing agent and oral care agent. It is classified as a Cosmetic Ingredient in our database. CAS number: 124-43-6.
What is the Margin of Safety for Carbamide Peroxide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Carbamide Peroxide?
The NOAEL (No Observed Adverse Effect Level) for Carbamide Peroxide is 100 ppm based on a oral study via oral route in mouse. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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