What is the NOAEL for 2,2-Dimethylpropane-1,3-diol?
2,2-Dimethylpropane-1,3-diol has 12 NOAEL studies in the database. The lowest reported value is 35 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2-Dimethylpropane-1,3-diol
Also known as: Neopentyl glycol, 4-01-00-02551, BRN 0605291, 2,2-Dimethyl-1,3 propanediol, Dimethyltrimethylene glycol (+2 more)
CAS 126-30-7
2,2-Dimethylpropane-1,3-diol (CAS 126-30-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
2,2-Dimethylpropane-1,3-diol is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
2,2-Dimethylpropane-1,3-diol
CAS Number
126-30-7
DTXSID
DTXSID8027036
Molecular Formula
C5H12O2
InChI Key
SLCVBVWXLSEKPL-UHFFFAOYSA-N
Monoisotopic Mass
104.08373
Synonyms
Neopentyl glycol4-01-00-02551BRN 06052912,2-Dimethyl-1,3 propanediolDimethyltrimethylene glycolEINECS 204-781-0UNII-QI80HXD6S5
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
SolventPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =35 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| QI80HXD6S5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QI80HXD6S5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QI80HXD6S5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QI80HXD6S5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=3200 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <=6400 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2-dimethylpropane-1,3-diol | 204-781-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184801
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,2-Dimethylpropane-1,3-diol?
2,2-Dimethylpropane-1,3-diol appears on 4 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, CEDI, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Is 2,2-Dimethylpropane-1,3-diol used in cosmetics?
Yes, 2,2-Dimethylpropane-1,3-diol is also indexed as a cosmetic ingredient under the name NEOPENTYL GLYCOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2-Dimethylpropane-1,3-diol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,2-Dimethylpropane-1,3-diol have different safety status in cosmetics vs industrial chemicals?
2,2-Dimethylpropane-1,3-diol is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is 2,2-Dimethylpropane-1,3-diol used outside industrial chemicals?
2,2-Dimethylpropane-1,3-diol also appears in cosmetics, pharmaceutical databases.