What is the NOAEL for 2,2-Dimethylpropane-1,3-diol?
2,2-Dimethylpropane-1,3-diol has 9 NOAEL studies in the database. The lowest reported value is 35 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,2-Dimethylpropane-1,3-diol
Also known as: Neopentyl glycol, 4-01-00-02551, BRN 0605291, 2,2-Dimethyl-1,3 propanediol, Dimethyltrimethylene glycol (+2 more)
CAS 126-30-7
2,2-Dimethylpropane-1,3-diol (CAS 126-30-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
2,2-Dimethylpropane-1,3-diol is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
9
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
12 fields
Name
2,2-Dimethylpropane-1,3-diol
CAS Number
126-30-7
Molecular Formula
C5H12O2
InChI Key
SLCVBVWXLSEKPL-UHFFFAOYSA-N
Monoisotopic Mass
104.08373
Synonyms
Neopentyl glycol4-01-00-02551BRN 06052912,2-Dimethyl-1,3 propanediolDimethyltrimethylene glycolEINECS 204-781-0UNII-QI80HXD6S5
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
12 records
SolventPlasticizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =35 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| QI80HXD6S5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=3200 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| <=6400 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HPVIS |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2-dimethylpropane-1,3-diol | 204-781-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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ChEMBL / DailyMed
CHEMBL3184801
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include 2,2-Dimethylpropane-1,3-diol?
2,2-Dimethylpropane-1,3-diol appears on 4 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, CEDI, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Is 2,2-Dimethylpropane-1,3-diol used in cosmetics?
Yes, 2,2-Dimethylpropane-1,3-diol is also indexed as a cosmetic ingredient under the name NEOPENTYL GLYCOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,2-Dimethylpropane-1,3-diol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2,2-Dimethylpropane-1,3-diol have different safety status in cosmetics vs industrial chemicals?
2,2-Dimethylpropane-1,3-diol is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is 2,2-Dimethylpropane-1,3-diol used outside industrial chemicals?
2,2-Dimethylpropane-1,3-diol also appears in cosmetics, pharmaceutical databases.