Is NEOPENTYL GLYCOL safe in cosmetics?
NEOPENTYL GLYCOL has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
NEOPENTYL GLYCOL
Also known as: 4-01-00-02551, BRN 0605291, 2,2-Dimethyl-1,3 propanediol, Dimethyltrimethylene glycol, EINECS 204-781-0 (+1 more)
NEOPENTYL GLYCOL (CAS 126-30-7) is a cosmetic cosmetic ingredient functioning as Plasticiser, Solvent. NOAEL 300 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 126-30-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
NEOPENTYL GLYCOL is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Plasticiser, Solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,2-dimethylpropane-1,3-diol
InChIKey
SLCVBVWXLSEKPL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for NEOPENTYL GLYCOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for NEOPENTYL GLYCOL across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0305
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Three rats were exposed to vapor at 4000 ppm for 6 hours a day for ten days. Symptoms of irritation of the respiratory tract /was/ detected.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Solvent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for NEOPENTYL GLYCOL.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to NEOPENTYL GLYCOL by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
4-01-00-02551
BRN 0605291
2,2-Dimethyl-1,3 propanediol
Dimethyltrimethylene glycol
EINECS 204-781-0
UNII-QI80HXD6S5
Chemical Function
Solvent
Plasticizer
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
CEDI
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184801
Frequently Asked Questions
Is NEOPENTYL GLYCOL allowed in the EU?
NEOPENTYL GLYCOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NEOPENTYL GLYCOL do in cosmetics?
NEOPENTYL GLYCOL functions as: Plasticiser, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 126-30-7.
What is the NOAEL for NEOPENTYL GLYCOL?
The NOAEL (No Observed Adverse Effect Level) for NEOPENTYL GLYCOL is =300 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is NEOPENTYL GLYCOL used outside cosmetics?
NEOPENTYL GLYCOL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does NEOPENTYL GLYCOL have different safety status in cosmetics vs industrial chemicals?
NEOPENTYL GLYCOL is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check NEOPENTYL GLYCOL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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