Also known as: Caswell No. 170, Chloramin Dr. Fahlberg, Chloramin Heyden, Chloramine T, (N-Chloro-p-toluenesulfonamido)sodium (+10 more)
CAS 127-65-1
Chloramine-T (CAS 127-65-1) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H314; H334. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Chloramine-T is classified GHS Danger (H302, H314, H334) in the chemicals database but is restricted in EU cosmetics at max 0.2%.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Corr. 1B; Resp. Sens. 1 | H302; H314; H334 | GHS07; GHS05; GHS08 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is severely irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; Personal care; restricted | European Commission | CosIng |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 291 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 259.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 314.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =19.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 100 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 99.5 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 248.4 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 328AS34YM6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 328AS34YM6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 328AS34YM6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 328AS34YM6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 404.7 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 50.23 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| >0.0042 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >0.275 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =935 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =75 | mg/kg bw/day | LOEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
| =225 | mg/kg bw/day | NOEL | dermal | Rabbit | ToxValDB_ECHA_IUCLID |
Showing 20 of 20 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tosylchloramide sodium | 204-854-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Chloramine-T (CAS 127-65-1) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Corr. 1B; Resp. Sens. 1 with signal word Danger. Hazard statements: H302; H314; H334. Source: EU CLP Annex VI (ECHA).
Chloramine-T has 20 NOAEL studies in the database. The lowest reported value is 0.0042 mg/L via Inhalation. Source: NTP_ICE_acute_inhalation.
Chloramine-T appears on 5 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 2 more. Source: EPA CPDat.
Yes, Chloramine-T is also indexed as a cosmetic ingredient under the name Chloramine T. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Chloramine-T is classified GHS Danger (H302, H314, H334) in the chemicals database but is restricted in EU cosmetics at max 0.2%.
Chloramine-T also appears in cosmetics, pharmaceutical databases.