Is Chloramine T safe in cosmetics?
Chloramine T has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Chloramine T
Also known as: Caswell No. 170, Chloramin Dr. Fahlberg, Chloramin Heyden, (N-Chloro-p-toluenesulfonamido)sodium, EINECS 204-854-7 (+9 more)
INCI: CHLORAMINE-T
Chloramine T (CAS 127-65-1) is a cosmetic cosmetic ingredient functioning as Preservative (antimicrobial). EU Regulation 1223/2009 status: restricted, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 127-65-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Chloramine T is classified GHS Danger (H302, H314, H317, H318, H334) in the chemicals database but is restricted in EU cosmetics at max 0.2%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative (antimicrobial)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
sodium chloro-(4-methylphenyl)sulfonylazanide
InChIKey
VDQQXEISLMTGAB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.2%
US US Status
permitted
US Notes
Permitted; FDA does not independently restrict but subject to general safety requirements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chloramine T.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is severely irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosiveHealth Hazard
Hazard Class and Category
Acute Tox. 4 *; Skin Corr. 1B; Resp. Sens. 1
Hazard Statements
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
100%
DPRA Lys %
99.5%
KeratinoSens IC50
404.692 µM
hCLAT CV75
314.7 µg/mL
LLNA EC3
5%
NESIL
1250 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Source: LLNA: ICCVAM database; DPRA: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; KS: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]; hCLAT: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008]
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
GROUP; SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Max: 0.002.
JPKR Japan/Korea Cosmetics
Japan (Positive (Preservative)): max 0.10
Japan (Restricted): max Wash-away: 0.30% | Leave-on: 0.10% | Mucosa: Prohibited
BRIN Brazil/India Cosmetics
India: Restricted · max 0.002
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | Wash-away: 0.30% | Leave-on: 0.10% | Mucosa: Prohibited | Wash-away: 0.30% | Leave-on: 0.10% | Mucosa: Prohibited |
| BR | restricted | 0.2 | - |
| ASEAN | restricted | 0.2% | All products |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0413
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (2)
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Chloramine T.
Regulatory Flags
preservative
eu_cosing_listed
Known Synonyms
Caswell No. 170
Chloramin Dr. Fahlberg
Chloramin Heyden
(N-Chloro-p-toluenesulfonamido)sodium
EINECS 204-854-7
EPA Pesticide Chemical Code 076502
NSC 36959
Tosylchloramid-natrium
UNII-328AS34YM6
Chlorina Aktivin
Chlorosol
Chlorseptol
Sodium p-toluenesulfonylchloramide
Tosylchloramidum natricum
Chemical Function
Biocide
Regulatory Lists
pharmaceutical
active_ingredient; Europe; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; Personal care; restricted
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHLORAMINE-T ANHYDROUS
ChEMBL ID
CHEMBL1697734
Max Phase
2
Frequently Asked Questions
Is Chloramine T allowed in the EU?
Chloramine T EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Chloramine T do in cosmetics?
Chloramine T functions as: Preservative (antimicrobial). It is classified as a cosmetic ingredient in our database. CAS number: 127-65-1.
Is Chloramine T used outside cosmetics?
Chloramine T also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Chloramine T have different safety status in cosmetics vs industrial chemicals?
Chloramine T is classified GHS Danger (H302, H314, H317, H318, H334) in the chemicals database but is restricted in EU cosmetics at max 0.2%.
Compliance Tools
Check Chloramine T compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
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