What is the NOAEL for D & C Green No. 6?
D & C Green No. 6 has 9 NOAEL studies in the database. The lowest reported value is 11.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
D & C Green No. 6
Also known as: 9,10-Anthracenedione, 1,4-bis[(4-methylphenyl)amino]-, D&C Green 6, Anthcoquinone Cyanine Green Base, 1,4-Bis(p-tolylamine)anthraquinone, BRN 2227927 (+12 more)
CAS 128-80-3
D & C Green No. 6 (CAS 128-80-3) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
D & C Green No. 6
CAS Number
128-80-3
DTXSID
DTXSID9044376
Molecular Formula
C28H22N2O2
InChI Key
TVRGPOFMYCMNRB-UHFFFAOYSA-N
Monoisotopic Mass
418.168128
Synonyms
9,10-Anthracenedione, 1,4-bis[(4-methylphenyl)amino]-D&C Green 6Anthcoquinone Cyanine Green Base1,4-Bis(p-tolylamine)anthraquinoneBRN 2227927EINECS 204-909-5Fat-soluble Anthraquinone GreenMacro-lex Green 5BMicro-lex Green 5BToyo Oriental Oil Blue GWaxoline GreenBis-1,4-p-tolylaminoanthrchinon
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
11 records
DyeFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| banned; Europe; Personal care | European Commission | CosIng |
| IFRA Transparency | IFRA | IFRA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Medical/dental | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =11.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4QP5U84YF7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QP5U84YF7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QP5U84YF7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QP5U84YF7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3660 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,4-bis(p-tolylamino)anthraquinone | 204-909-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorants
Frequently Asked Questions
What regulatory lists include D & C Green No. 6?
D & C Green No. 6 appears on 7 regulatory/inventory lists including Europe; Personal care, banned; Europe; Personal care, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is D & C Green No. 6 used in cosmetics?
Yes, D & C Green No. 6 is also indexed as a cosmetic ingredient under the name CI 61565. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D & C Green No. 6 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is D & C Green No. 6 used outside industrial chemicals?
D & C Green No. 6 also appears in cosmetics databases.