NOAEL Data Cosmetic Ingredient

1,4-Diaminoanthraquinone

Also known as: C.I. Disperse Violet 9, 1,4-Anthraquinonyldiamine, Celliton Fast Red Violet R, Cibacet Violet E2R, Cibacete Violet 2R (+10 more)

CAS 128-95-0

1,4-Diaminoanthraquinone (CAS 128-95-0) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.

View cosmetic safety profile for Disperse Violet 1 →

Cross-Vertical Regulatory Divergence

1,4-Diaminoanthraquinone is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H301, H317, H373).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

1,4-Diaminoanthraquinone

CAS Number

128-95-0

DTXSID

DTXSID2041252

Molecular Formula

C14H10N2O2

InChI Key

FBMQNRKSAWNXBT-UHFFFAOYSA-N

Monoisotopic Mass

238.074228

Synonyms

C.I. Disperse Violet 91,4-AnthraquinonyldiamineCelliton Fast Red Violet RCibacet Violet E2RCibacete Violet 2R1,4-Diamino-9-10-anthraquinoneDispersive Violet KDuranol Violet 2R, 1,4-diamino-EINECS 204-922-6Interchem Disperse Violet 2RHLurafix Red Violet RNMideton Fast Red Violet R

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 6 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 64 studies

Value	Unit	Endpoint	Route	Species	Source
40	mg/kg bw/d	-	-	-	Regulatory source
160	mg/kg bw	-	-	-	Regulatory source
160	mg/kg bw	-	-	-	Regulatory source
8.20890019925237	uM	AC50	-	-	NTP ICE endocrine
62.33937348	uM	ACC	-	-	NTP ICE endocrine
N21HDQ0TKN	UNII	FDA UNII substance identifier	-	-	openFDA substances
N21HDQ0TKN	UNII	FDA UNII substance identifier	-	-	openFDA substances
N21HDQ0TKN	UNII	FDA UNII substance identifier	-	-	openFDA substances
N21HDQ0TKN	UNII	FDA UNII substance identifier	-	-	openFDA substances
=5790	mg/kg bw	LD50	oral	Rat	NTP ICE acute oral
2	mg/kg bw/day	LOAEL	oral	rat	COSMOS DB
-	unitless	Model Score	-	-	NTP ICE endocrine
0.0102	unitless	Model Score	-	-	NTP ICE endocrine
=0.003	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=0.003	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=0.003	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=0.003	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
0.25	mg/kg bw/day	NOAEL	oral	rat	COSMOS DB
=1.21	mg/kg	NOAEL	-	guinea pig	SCCNFP Opinion
=1.21	mg/kg/day	NOAEL	oral	rat	SCCNFP Opinion
=1.21	mg/kg	NOAEL	-	guinea pig	SCCNFP Opinion
=1.21	mg/kg/day	NOAEL	oral	rat	SCCNFP Opinion
=1.21	mg/kg	NOAEL	-	guinea pig	SCCNFP Opinion
=1.21	mg/kg/day	NOAEL	oral	rat	SCCNFP Opinion
=1.21	mg/kg	NOAEL	-	guinea pig	SCCNFP Opinion
=1.21	mg/kg/day	NOAEL	oral	rat	SCCNFP Opinion
=2	mg/kg/day	NOAEL	-	-	SCCS Opinion
=2	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=2	%	NOAEL	dermal	human	SCCNFP Opinion
=2	mg/kg/day	NOAEL	-	-	SCCS Opinion
=2	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=2	mg/kg/day	NOAEL	-	-	SCCS Opinion
=2	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=2	%	NOAEL	dermal	human	SCCNFP Opinion
=2	%	NOAEL	dermal	human	SCCNFP Opinion
=2	mg/kg/day	NOAEL	-	-	SCCS Opinion
=2	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=2	%	NOAEL	dermal	human	SCCNFP Opinion
=40	mg/kg bw	NOAEL	-	human	SCCS Opinion
=40	mg/kg bw/d	NOAEL	dermal	rat	SCCS Opinion
=40	mg/kg bw	NOAEL	-	human	SCCS Opinion
=40	mg/kg bw/d	NOAEL	dermal	rat	SCCS Opinion
=40	mg/kg bw	NOAEL	-	human	SCCS Opinion
=40	mg/kg bw/d	NOAEL	dermal	rat	SCCS Opinion
=40	mg/kg bw	NOAEL	-	human	SCCS Opinion
=40	mg/kg bw/d	NOAEL	dermal	rat	SCCS Opinion
=160	mg/kg bw	NOAEL	-	-	SCCS Opinion
=160	mg/kg bw	NOAEL	-	-	SCCS Opinion
=160	mg/kg bw	NOAEL	-	-	SCCS Opinion
=160	mg/kg bw	NOAEL	-	-	SCCS Opinion

Showing 50 of 64 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1400/10	22 June 2010	not safe	-	sensitisation; potential systemic toxicity concerns

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

0.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL86771

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,4-Diaminoanthraquinone?

1,4-Diaminoanthraquinone has 64 NOAEL studies in the database. The lowest reported value is 0.003 mg/kg bw via oral in rat. Source: Regulatory source.

What regulatory lists include 1,4-Diaminoanthraquinone?

1,4-Diaminoanthraquinone appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, inert_ingredient; non_food_use; Pesticides, Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 1,4-Diaminoanthraquinone used in cosmetics?

Yes, 1,4-Diaminoanthraquinone is also indexed as a cosmetic ingredient under the name Disperse Violet 1. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,4-Diaminoanthraquinone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,4-Diaminoanthraquinone have different safety status in cosmetics vs industrial chemicals?

1,4-Diaminoanthraquinone is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H301, H317, H373).

Is 1,4-Diaminoanthraquinone used outside industrial chemicals?

1,4-Diaminoanthraquinone also appears in cosmetics, pharmaceutical databases.